A new series of potential epidermal growth factor receptor inhibitors possessing bisquinazoline and saccharide moieties were designed and synthesized. The biological results demonstrated that the synthetic derivatives significantly inhibited epidermal growth factor receptor enzymatic activity in vitro. Of them, compound 14b showed the highest inhibitory rate toward epidermal growth factor recep...

An aromatic amino acid is present in the binding site of a number of sugar binding proteins. The interaction of the saccharide with the aromatic residue is determined by their relative position as well as orientation. The position-orientation of the saccharide relative to the aromatic residue was found to vary in different sugar-binding proteins. In the present study, interaction energies of th...

Ricinus communis agglutinin was subjected to various chemical treatments and the effect on its hemagglutinating and saccharide-binding properties was studied. Acetylation, succinylation and citraconylation led to a complete loss in the activity of the agglutinin, whereas reductive methylation had no effect on the activity, showing that charged amino groups were involved in the hemagglutinating ...

Between 100 kHz and 2 GHz ultrasonic attenuation spectra of disaccharides in water have been measured at 25 degrees C. Some additional measurements have been performed at different temperatures between 10 and 35 degrees C and as a function of saccharide concentration c (0.5 mol/l</=c</=1.8 mol/l). The analytical description of the spectra in terms of relaxation spectral functions revealed four ...

A mutant hen egg white lysozyme, D52E, was designed to correspond to the structure of the mutant T4 lysozyme T26E (Kuroki, R., Weaver, L. H., and Matthews B. W. (1993) Science 262, 2030-2033) to investigate the role of the catalytic residue on the alpha-side of the saccharide in these enzymes. The D52E mutant forms a covalent enzyme-substrate adduct, which was detected by electron ion spray mas...

Concanavalin A (Con A) is the best known plant lectin, with important biological properties arising from its specific saccharide-binding ability. Its exact biological role still remains unknown. The complex of Con A with 4'-methylumbelliferyl-alpha-D-glucopyranoside (alpha-MUG) has been crystallized in space group P2(1) with cell dimensions a = 81.62 A, b = 128.71 A, c = 82.23 A, and beta = 118...

A bioinspired one-pot approach for the synthesis of ZnO-carbohydrate hierarchical architectures was developed. The synergy between a saccharide (mono-, di- or polysaccharide) that contains d-glucose units and triethanolamine is the key parameter of the synthetic methodology. The morphology of the ZnO composites is dictated by the saccharide used, and rod, spindle, solid and hollow spherical-lik...

BACKGROUND Recently synthesized novel oligosaccharides have been produced primarily by hydrolases and glycosyltransferases, while phosphorylases have also been subject of few studies. Indeed, phosphorylases are expected to give good results via their reversible reaction. The purpose of this study was to synthesis other novel oligosaccharides using kojibiose phosphorylase. RESULTS Three novel ...

large reserves of coal in tabas region of iran are characterized by low ash and high caking index, suitable for use in metallurgy as coking coal. however, these coals cannot be gainfully utilized because of their high sulfur content. in this work, studies on desulfurization of tabas coals were carried out in a batch reactor using various reagents. the most effective reagents, fe2(so4)3 , fecl3 ...