Pavlačík L., V. Celer Jr., V. Kajerová, V. Jekl, Z. Knotek, I. Literák: Monitoring of Antibodies Titre Against Canine Distemper Virus in Ferrets Vaccinated with a Live Modifi ed Vaccine. Acta Vet. Brno 2007, 76: 423-429. A group of fi ve ferrets vaccinated against the canine distemper virus (CDV) was evaluated as to the onset of anti-CDV antibody production and the serum levels of the animals w...

The hemagglutinin (HA) genes of the influenza A H3N2 subtype viruses isolated from 1968 to 2010 have evolved substantially but their neuraminidase (NA) genes have been relatively less divergent. The H3N2 viruses isolated since 1995 were found to replicate in the lower respiratory tract of ferrets less efficiently than the earlier isolates. To evaluate whether the HA or/and NA or the internal pr...

An epizootic of toxoplasmosis occurred among 22 adult and 30 kit black-footed ferrets (Mustela nigripes) maintained under quarantine conditions at the Louisville Zoological Garden (Louisville, Kentucky, USA) in June, 1992. Black-footed ferrets appear to be highly susceptible to acute and chronic toxoplasmosis. Clinical signs were observed in 19 adults and six kits and included anorexia, letharg...

Pain is present with many diseases as well as in association with surgical and traumatic conditions. The demonstration of pain is not always obvious; therefore, an animal should be assumed to be experiencing pain in any condition expected to produce pain in humans. The assessment and control of pain is an art as well as a science. Clinicians should keep in mind that the art of pain management i...

Eosinophilic gastroenteritis, focal or diffuse with eosinophilic infiltrations of the stomach or intestine, has been described in human beings, cats, dogs, and horses. In this paper, we describe infiltration of the gastrointestinal tract with eosinophils accompanied by a circulating eosinophilia in six ferrets (Mustela putorius furo). Clinical signs included chronic weight loss, anorexia, and d...

The experiments described confirm the earlier observation of Smith, Andrewes, and Laidlaw that the swine influenza virus is pathogenic for ferrets when administered intranasally. A disease that is clinically more severe and pathologically more extensive than that described by the above workers is obtained if inoculation with the virus is performed under ether anesthesia. Animals infected in thi...

The purpose of this study was to determine whether the cardiac contractile abnormalities induced by hyperthyroidism or hypothyroidism are caused by changes in intracellular Ca2+ handling or by alterations in the distribution of isoenzymes of ventricular myosin. Right ventricular papillary muscles obtained from euthyroid ferrets and ferrets treated with L-thyroxine (hyperthyroid) or methimazole ...

Identification of cellular receptors and characterization of viral tropism in animal models have vastly improved our understanding of morbillivirus pathogenesis. However, specific aspects of viral entry, dissemination and transmission remain difficult to recapitulate in animal models. Here, we used three virologically identical but phenotypically distinct recombinant (r) canine distemper viruse...

1. Swine influenza virus obtained from the lungs of infected ferrets or mice, when administered intramuscularly or subcutaneously, immunizes swine to swine influenza. 2. Ferrets, which have received subcutaneous injections of swine influenza virus obtained from the lungs of infected ferrets, are immune to intranasal infection with this virus. Similar injections with virus from the lungs of infe...

OBJECTIVES The emergence of the pandemic influenza A(H1N1)pdm09 virus in 2009 saw a significant increase in the therapeutic and prophylactic use of neuraminidase inhibitors (NAIs) to mitigate the impact of this highly transmissible virus. Prior to the pandemic, many countries stockpiled NAIs and developed pandemic plans for the use of antiviral drugs, based on either treatment of high-risk indi...