Nonalcoholic steatohepatitis (NASH) is associated with caspase activation. However, a role for pro-inflammatory caspases or inflammasomes has not been explored in diet-induced liver injury. Our aims were to examine the role of caspase-1 in high fat-induced NASH. C57BL/6 wild-type and caspase 1-knockout (Casp1(-/-)) mice were placed on a 12-week high fat diet. Wild-type mice on the high fat diet...

1. In 125 cases of perirenal fat samples derived from human necropsies (from 1 month to 86 years), the occurrence of the brown adipose tissue was examined. Brown fat cells were contained in 72% (90: 125) of the cases. 2. In the infants, all samples contained maximal amounts of brown fat cells: the perirenal fat was composed almost exclusively of brown fat cells: in children and teenagers they b...

OBJECTIVE The purpose of this study was to determine whether type 2 diabetic patients have more liver fat than age-, sex-, and BMI-matched nondiabetic subjects and whether liver enzymes (serum alanine aminotransferase [S-ALT] and serum aspartate aminotransferase) are similarly related to liver fat in type 2 diabetic patients and normal subjects. RESEARCH DESIGN AND METHODS Seventy type 2 diab...

Introduction: Research shows a relationship between diabetes (type II) and obesity. Bioelectrical Impedance Analysis (BIA) is a relatively new and approved method for the measurement of body composition. The aim of this study was to compare diabetic and non-diabetic adults on the basis of waist-hip ratio, total fat, percentage of fat, trunk fat, and soft lean mass. Methods: In this cross-sec...

FAT/CD36 is a transmembrane protein that is thought to facilitate cellular long-chain fatty acid uptake. However, surprisingly little is known about the localization of FAT/CD36 in human skeletal muscle. By confocal immunofluorescence microscopy, we demonstrate high FAT/CD36 expression in endothelial cells and weaker but significant FAT/CD36 expression in sarcolemma in human skeletal muscle. No...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : recently autologous fat tissue transfer has gained much popularity. on the other hand, applying the transferring methods with a higher survival rate is still controversial. the aim of this study is to compare dermis-fat graft and dermal-fascia-fat graft. methods : this animal study was conducted in 2008-2009. ...

BACKGROUND The high-fat Western diet is postulated to be associated with the onset and progression of Alzheimer's disease (AD). However, the role of high-fat-diet consumption in AD pathology is unknown. This study was undertaken to examine the role of high-fat-diet intake in AD. METHODS AND RESULTS 5XFAD mice, a useful mouse model of AD, and control wild-type mice were fed (1) high-fat diet o...