The decision of a growing axon to selectively fasciculate with and defasciculate from other axons is critical for axon pathfinding and target innervation. Fasciculation can be regulated by cell adhesion molecules that modulate interaxonal adhesion and repulsive molecules, expressed by surrounding tissues that channel axons together. Here we describe crosstalk between molecules that mediate thes...

The decision of a growing axon to selectively fasciculate with and defasciculate from other axons is critical for axon pathfinding and target innervation. Fasciculation can be regulated by cell adhesion molecules that modulate interaxonal adhesion and repulsive molecules, expressed by surrounding tissues that channel axons together. Here we describe crosstalk between molecules that mediate thes...

To probe for the role of the L1 cell surface glycoprotein during neurite outgrowth and fasciculation in the early postnatal mouse cerebellar cortex, a microexplant culture system was used. Fasciculation of neurites was reduced in the presence of antigen-binding fragments (Fab) of poly- and monoclonal L1 antibodies, as compared to untreated controls. In addition, speed of neurite outgrowth was e...

The formation of precise stereotypic connections in sensory systems is critical for defining accurate internal representations of the external world; however, the molecular mechanisms underlying the formation of sensory maps are poorly understood. Here, we examine the roles of two structurally unrelated repulsive guidance cues, semaphorin 3F (Sema3F) and Slit-1, in olfactory sensory axon fascic...

Objectives: In this study, in order to review the semiology of traditional medicine and apply it to current medical terminology, traditional and classic medicine resources on the subject of convulsion were reviewed. The connotative meaning of the term “convulsion” in traditional medicine is “the twitch of a non-specific part of the body, prepared for an expansive movement in a consistent, rapid...

BACKGROUND Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine. METHODS This randomized, double-blinded study was conducted in 100...

A practical issue in the diagnosis of amyotrophic lateral sclerosis (ALS) is how long the EMG must be observed before a muscle can be declared free of fasciculations with some degree of certainty. To answer this question, the intervals between fasciculation potentials (FPs) were recorded from 53 muscles of 19 ALS patients. The distribution of the FP intervals found across the sample showed that...