A homozygous mutation in the RAD51C gene was recently found to cause Fanconi anemia-like disorder. Furthermore, six heterozygous deleterious RAD51C mutations were detected in German breast and ovarian cancer families. We screened 277 Finnish familial breast or ovarian cancer patients for RAD51C and identified two recurrent deleterious mutations (c.93delG and c.837+1G>A). These mutations were fu...

Mutations in DNA repair genes are known for their association with hereditary breast cancer. BRCA1 and BRCA2 are the major genes for high-penetrance familial breast and ovarian cancer, whereas mutations in ATM or Chek2 confer more modest cancer risk. Additional genes involved in DNA double-strand break repair have more recently been associated with breast cancer risk: heterozygosity for deleter...

The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for a...

background and purpose: breast cancer is the most common cause of cancer-specific mortality among women worldwide. this study aimed at investigating the epidemiological, clinical, and pathological characteristics of breast cancer among patients attending baghban clinic in sari. materials and methods: the patients’ records (2008-2014) were used and data including age, gender, marital status, men...

Abstract: Background: Early detection of breast cancer has a direct relationship with women's knowledge about breast cancer and its screening methods. Knowledge, attitude, and behavior of women in Yazd haven't yet surveyed, however breast cancer is one of health institute's priorities. The objective of this study is to survey the knowledge, attitude, and behavior regarding breast cancer screen...

The known breast cancer susceptibility genes only account for 20% to 25% of the excess familial risk of the disease 1. The present study assessed the contribution of BRCA1/2 mutations and CHEK2 variants to the relative risk of breast cancer for women with affected mothers or sisters. The familial relative risks were estimated by Poisson regression based on the Swedish Family-Cancer Database. Th...

breast cancer is the most common malignancy in women in many parts of the world. the risk factors for breast cancer cover a broad range of conditions, from age to complex genetic alterations. present data is showing an increase in the annual incidence rates of disease and it is ranked as the first recorded malignancies among iranian women after 1999. to study the association of reproductive and...

The genetic cause for approximately 80% of familial breast cancer patients is unknown. Here, by sequencing the entire exomes of nine early-onset familial breast cancer patients without BRCA1/2 mutations (diagnosed with breast cancer at or before the age of 35) we found that two index cases carried a potentially deleterious mutation in the RECQL gene (RecQ helicase-like; chr12p12). Recent studie...

abstract background: the aim of this study was to investigate the various aspects of illness perceptions about breast cancer in affected patients. methods: a cross-sectional study enrolled 140 patients with breast cancer in their chemotherapy period within 14 months. the revised illness perception questionnaire (revised ipq) was used to assess the disease representations of breast cancer. the d...