We present a case of chronic periprosthetic hip infection diagnosed using the Musculoskeletal Infection Society criteria as the gold standard. The alpha-defensin test was falsely negative. The diagnostic workup of the patient is detailed, along with a discussion regarding the potential reasons behind the misleading alpha-defensin results. To our knowledge, this is the first reported case of a f...

The implementation of a number of chemical carcinogen screening programs has been accompanied by the observation that some screens might have high false-positive error rates. With designs presently used at the National Cancer Institute and historical spontaneous tumor rates based upon control animals in previous experiments, we compute upper bounds on the false-positive error rates for several ...

To determine the number of false-negative results produced by inefficient extraction of drugs from meconium, three published procedures were compared by using previously confirmed positive and negative meconium specimens. The methods were not equivalent in their ability to extract drugs from the matrix. To determine the number of false positives reported by the use of screen-only (unconfirmed) ...

Quantitative and histochemical nitroblue with polycythemia vera and neoplasia astetrazolium reduction (NBT) tests were persociated with fever, as well as in those with formed on leukocytes of 13 patients with known bacterial infection. It is suggested polycythemia vera, seven with chronic that patients with neoplasia or polycygranulocytic leukemia, eight with neothemia vera may show a false pos...

One of the more discouraging trends in the literature of drug testing is the rate at which the toxicology community seems willing to accept imprecision in the use of its technical terms of art. This practice never fails to evoke derision when detected in lay commentary, but I am increasingly struck by the convergence of professional and lay literature in this respect. In the drug testing litera...

The ratio of false-positive to false-negative findings (FP:FN ratio) is an informative metric that warrants further evaluation. The FP:FN ratio varies greatly across different epidemiologic areas. In genetic epidemiology, it has varied from very high values (possibly even >100:1) for associations reported in candidate-gene studies to very low values (1:100 or lower) for associations with genome...