Environmental factors during fetal development can induce a permanent epigenetic change in the germ line (sperm) that then transmits epigenetic transgenerational inheritance of adult-onset disease in the absence of any subsequent exposure. The epigenetic transgenerational actions of various environmental compounds and relevant mixtures were investigated with the use of a pesticide mixture (perm...

The stability of transgene transmission, milk production and milk content of recombinant human protein C (rhPC) in transgenic rabbits of the F3 generation was determined. Transgenic rabbits carrying the 4.2kb mouse whey acid protein promoter and 9.4kb genomic human protein C were produced after mating transgenic (F2 generation) and non-transgenic rabbits. PCR analysis of F3 samples showed that ...

The term “obesogen” describes a chemical that promotes excessive weight gain by increasing adipocyte (fat cell) size or number, changing metabolism to favor fat storage, or altering the control of appetite and satiety. Previous studies have suggested that prenatal exposure to obesogens can alter metabolism in mice and predispose multipotent mesenchymal stem cells (MSCs) to become fat cells, but...

Exposure to environmental factors can induce the epigenetic transgenerational inheritance of disease. Alterations to the epigenome termed "epimutations" include "primary epimutations" which are epigenetic alterations in the absence of genetic change and "secondary epimutations" which form following an initial genetic change. To determine if secondary epimutations contribute to transgenerational...

The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adult o...

The deleterious consequences of inbreeding have been well documented. There are, however, few empirical studies that have examined the consequences of restoring heterozygosity and hence the fitness of inbred populations by conducting interpopulation crosses and measuring the performance of later-generation hybrids under field conditions. We conducted interpopulation crosses of 100 m to 2000 km,...

In order to evaluate the relationship between morphological characters in rice lines two populations at F3 generation were grown in research field of Agricultural Sciences and Natural Resource University, Sari, Iran, during 2012. Statistical analysis on important agronomic traits showed that maximum standard deviation belonged to total grain number followed by filled grains per panicle and grai...