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Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1.
Hsp70 chaperones mediate folding of proteins and prevent their misfolding and aggregation. We report here on a new kind of Hsp70 interacting protein in mitochondria, Hep1. Hep1 is a highly conserved protein present in virtually all eukaryotes. Deletion of HEP1 results in a severe growth defect. Cells lacking Hep1 are deficient in processes that need the function of mitochondrial Hsp70s, such as...
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It is a pleasure to be able to introduce this second Thematic Series on ‘organo-fluorine chemistry’ within the Beilstein Journal of Organic Chemistry. The series now embeds the subject firmly as a special interest area of the journal. The first series in 2008 presented contributions representing a wide range of organic fluorine chemistry [1-10] and this series continues that trend exploring the...
Vacancies play a pivotal role in affecting ferroelectric polarization and switching properties, and there is a possibility that ferroelectricity may be utterly eliminated when defects render the system metallic. However, sufficient quantitative understandings of the subject have been lacking for decades due to the fact that vacancies in ferroelectrics are often charged and polarization in charg...
Over the past 40 years, much of the author's research, both computational and experimental, has involved collaborations. This Perspective describes some of the author's collaborative research in eight different areas of organic and theoretical chemistry: (1) hydrocarbons containing unsaturatively, 1,3-bridged cyclobutane rings, (2) the use of orbital topology for predicting the ground states of...
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