Aquaporins (AQPs) are a family of ubiquitous membrane channels that conduct water across cell membranes. AQPs form homotetramers containing four functional and independent water pores. Aquaporin-0 (AQP0) is expressed in the eye lens, where its water permeability is regulated by calmodulin (CaM). Here we use a combination of biochemical methods and NMR spectroscopy to probe the interaction betwe...

Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO•) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The present study focused on electron transfer ability of resting state CaM-free nNOS in presence of dinitrobenzene isomers (DNBs). NADPH oxidation (NADPH ox ) and acetylated cytochrome-c reduction (AcCyt-cred ) catalyzed by ...

November 2006 In This Issue ● Bread and Kidney Cancer ● Nursing and CAM ● Occlusion Therapy for Lazy Eye in Children ● Joint Library Conference ● Aromatherapy and Recreational Diving ● CAM for Radiation Therapy ● NBScience International Conference of Biomedical Sciences ● Inside Natural Standard Natural Standard provides high quality, evidence-based information about complementary and alternati...

Inositol 1 ,4,5-trisphosphate (InsP3) 3-kinase is responsible for the synthesis of InsP4. The kinase in many tissues is regulated by Ca2+/calmodulin (CaM; see [1] for review). The activity of purified enzyme from bovine brain is stimulated up to 30-fold by Ca2+/CaM. Stimulation by CaM appears to result from an increase in enzyme maximal velocity without a substantial change of Km for InsP3 [2]....

Binocular vision relies upon the existence of contralateral and ispilateral projections from retinal ganglion cells. Contacts between visual axons and optic chiasm cells are critical for the sorting of crossed and uncrossed projections during development. In this issue of Neuron, a study by Williams et al. shows that the cell adhesion molecule Nr-CAM facilitates/promotes the decussation of cont...

Infectious Laryngotracheitis (ILT) is an acute highly contagious respiratory disease of chickens. It has significant economic importance due to mortalities and the decrease in egg production. In this study, twenty nine samples from different layer farms were collected outbreaks that occurred waset province, Iraq, at period November 2021 till March 2022 detect ILTV by molecular test through real...