Lactic acid bacteria are industrially important microorganisms recognized for their fermentative ability mostly in their probiotic benefits as well as lactic acid production for various applications. Nevertheless, lactic acid fermentation often suffers end-product inhibition which decreases the cell growth rate. The inhibition of lactic acid is due to the solubility of the undissociated lactic ...

A new approach to control structure analysis and design for nonlinear multivariable systems is proposed in this paper. By integrating the concept of gap metric, factorial design and multivariate projection methods, a systematic analysis of control structures, operating conditions and operating regime based control strategies can be established. The application to an extractive fermentation proc...

The present work proposes a control parameter adjustment technique using Kalman filter applied to an adaptive control strategy. The control algorithm is based on neural networks with on-line learning to compute the next action of the manipulated process variables. The penalization parameters of the control actions are on-line optimised by the Kalman filter. The control strategy was tested on an...

The presented work addresses the integrated design of solvent molecules with separation and reactive-separation process systems. The proposed design philosophy relies on extensive structural optimization both at the solvent and process synthesis stage and allows the identification of solvent molecules based on process performance criteria. It employs multi-objective optimization technology in o...

Owing to recent developments in molecular biology and biotechnology, we have seen rapid growth in the development of industrial processes to produce valuable substances by microbial means. The idea is not new to the fermentation technologist because they are the means for producing beverages, antibiotics, and many other complex organic materials for commercial use. There are some inherent engin...

Monascus pigments produced by Monascus spp. are widely used as natural food colourants. Extractive fermentation technology can facilitate the secretion of intracellular Monascus pigments into extracellular non-ionic surfactant micelle aqueous solution, so as to avoid the feedback inhibition and decomposition. In this study, behaviour of the trans-membrane secretion of Monascus pigments was inve...

In this paper, the methodology for complete partial control design based on a novel PCA-based technique incorporating the inventory and constraint control objectives is described. Brief descriptions on the PCA-based technique, some definitions and criteria are also presented. The application of the methodology is demonstrated using a case study of extractive alcoholic fermentation process. Resu...