Background: Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triple-negative phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present study attempted to compare the BRCA1 expression in triple-negative with lu...

Introduction: The implantation is a complex procedure that involves many molecules. One of these molecules is integrin specially &alphav&beta3 which serves as receptor for components of extra cellular matrix to act as bridging molecules between the blastocyst and the endometrial surface during the implantation process. By blocking &alphav&beta3 interactions, the implantation can be impaired. ...

introduction: oral delivery is the most favorable route for insulin administration. the aim of this study was to generate new chitosan coated insulin nanoliposomes and then to assess the physiological efficacy of these nanoliposomes after oral administration in diabetic rabbits. methods: nanoliposomes with negative surface charge encapsulating insulin were prepared by reverse phase evaporation ...

Pneumorrhachis (PR), which involves the entrapment of air or gas within the spinal canal, is a rare clinical entity. The pathogenesis and etiology of this uncommon entity vary and may present a diagnostic challenge. Air in the spinal canal can be divided into primary and secondary PR, extra- or intradural PR and etiologically classified as iatrogenic, traumatic and non-traumatic. PR is typicall...

The case of an 18-year-old girl with Superior Mesenteric Artery syndrome is presented here. She to us complaints anorexia, nausea, vomiting, and weight loss for the past year. was cachectic volume-depleted. All investigations preliminary imaging were inconclusive. Upper GI endoscopy revealed normal structure up second part duodenum. Contrast-enhanced Computerized Tomography abdomen pelvis did n...

pneumorrhachis (pr), which involves the entrapment of air or gas within the spinal canal, is a rare clinical entity. the pathogenesis and etiology of this uncommon entity vary and may present a diagnostic challenge. air in the spinal canal can be divided into primary and secondary pr, extra- or intradural pr and etiologically classified as iatrogenic, traumatic and non-traumatic. pr is typicall...