The invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands. Parasite proteins that bind erythrocyte receptors during invasion are localized in apical organelles called micronemes and rhoptries. The regulated secretion of microneme and rhoptry proteins to the merozoite surface to enable receptor binding is a critical step in t...

PURPOSE To evaluate the condition of the tendons and neurovascular bundles after percutaneous release for trigger finger of the middle, ring, and little fingers. METHODS 30 women and 13 men aged 20 to 55 (mean, 40) years underwent percutaneous release of the A1 pulley using a 18-gauge needle for 43 trigger fingers of the middle, ring, or little finger unresponsive to conservative treatment. 1...

Affinity-based cell separation is label-free and highly specific, but it is difficult to efficiently and gently release affinity-captured cells due to the multivalent nature of cell-material interactions. To address this challenge, we have developed a platform composed of a capture substrate and a cell-releasing molecular trigger. The capture substrate is functionalized with a cell-capture anti...

Stimuli-responsive materials undergo structural changes in response to an external trigger (i.e., pH, heat, or light). This process has been previously used for a range of applications in biomedicine and microdevices and has recently gained considerable attention in controlled drug release. Here, we use a near-infrared (NIR) light responsive polymer-nanorod composite whose glass transition temp...

Reproduction in fishes is regulated by external environmental factors that trigger internal mechanisms into action. The final event of the reproductive cycle, the release of eggs and sperm resulting in spawning, can be controlled by either placing the fish in an appropriate environment or by changing the fish’s internal regulating factors with injected hormones or other substances. The internal...

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

Objectives: This study aimed to evaluate the safety and effectiveness of percutaneous release trigger digit compare results with that open surgery .
 Methods: Those patients have been submitted according Green grading severity (grade II & III), then divided into 2 groups randomly each 26 patients. The 1st group has treated 2nd release. Patients both procedures followed up for 8 days 28...