new blood forming vessels are produced by differentiation of mesodermal precursor cells to angioblasts that become endothelial cells (ecs) which in turn give rise to primitive capillary network. human cord blood (hcb) contains large subsets of mononuclear cells (mncs) that can be differentiated into endothelial-like cells in vitro. human mononuclear progenitor cells were purified from fresh umb...

Background: The stress is one of main factors effects on production system. Several factors (both genetic and environmental elements) regulate immune response to stress. Objectives: In order to determine the major immune system regulatory genes underlying stress responses, a learning Bayesian network approach for those regulatory genes was applied to RNA-...

we have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. this network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...

Background and objectives: Curcumin as a medicinal substance has shown effective in different kinds of diseases especially cancer. To understand its underlying mechanism, molecular complementary study of differentially expressed microRNAs (DEMs) could assist. In this view, regulatory network analysis of DEMs of melanoma cancer treated with curcumin versus the untreated male <em...

We have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. This network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...

As an aromatic and colorful plant of substantive taste, saffron (Crocus sativus L.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. Regarding the critical role of microRNAs in secondary metabolic synthesis and the limited number of identified miRNAs in C. sativus, on the other hand, one may see the point how the characte...

objective: despite the huge efforts, chronic kidney disease (ckd) remains as an unsolved problem in medicine. many studies have shown a central role for transforming growth factor beta-1 (tgfβ-1) and its downstream signaling cascades in the pathogenesis of ckd. in this study, we have reanalyzed a microarray dataset to recognize critical signaling pathways controlled by tgfβ-1. materials and met...