introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with mult...

Ambient temperature is one of the most important environmental factors affecting physiological mechanisms and biochemical reactions of living organisms. Thus the effect of ambient temperature on HSPs and IGF-I gene expression levels in the liver and muscle tissues of Sparus aurata were investigated in this research. The levels of HSPs, and IGF-I gene expression of the liver and muscle of Sparus...

Objective(s): Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and ...

Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated t...

Background: It is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. Lysine-specific demethylase 5D (KDM5D) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl H3K4 at the start site of active genes. In this light, the aim of this study was to invest...

The category of finite cardinals (or, equivalently, of finite sets) is the symmetric analogue of the category of finite ordinals, and the ground category of a relevant category of presheaves, the augmented symmetric simplicial sets. We prove here that this ground category has characterisations similar to the classical ones for the category of finite ordinals, by the existence of a universal sym...

An algebraic classification of second order symmetric tensors in 5-dimensional Kaluza-Klein-type Lorentzian spaces is presented by using Jordan matrices. We show that the possible Segre types are [1, 1111], [2111], [311], [z z̄ 111], and the degeneracies thereof. A set of canonical forms for each Segre type is found. The possible continuous groups of symmetry for each canonical form are also stu...

Objective(s): The beneficial and more potent role of exercise to prevent heart apoptosis in ovariectomized rats has been known. The aim of this study was to examine the effects of swimming training on cardiac expression of Bcl-2, and Mir-133 levels and glycogen changes in the myocyte. Materials and Methods: Forty animals were separated into four groups as control, sham, ovariectomy (OVX) and o...

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and insulin secretory defect. Deficiency of cellular immunity is known as one of the factors involved in the pathogenesis of T2DM. lymphocyte-specific protein tyrosine kinase( LCK) is an important gene involved in the intracellular signaling pathways of lymphocytes. This study aimed at determining and comparing LCK gene expr...