Modern drug discovery is primarily based on the search and subsequent testing of drug candidates acting on a preselected therapeutic target. Progress in genomics, protein structure, proteomics, and disease mechanisms has led to a growing interest in and effort for finding new targets and more effective exploration of existing targets. The number of reported targets of marketed and investigation...

This study addresses the use of predictive modeling techniques; primarily feed-forward artificial neural networks as a tool for forecasting geological exploration targets for gold prospecting. It also provides evidence of effectiveness of using Business Intelligence systems to model pathfinder variables, anomaly detection, and forecasting to locate potential exploration sites for precious metal...

Geothermal exploration has been highly successful to date in locating targets for drilling. However, the requirements for an economically successful geothermal well are both high flow rat,e and high temperature. Most geophysical and geochemical exploration methods have not been highly accurate in predicting the depth and actual temperature of a reservoir, nor have they been able to locate high ...

This research presents a collaborative evolutionary planning framework for large scale grid exploration and planning problems. It caters for both dynamic and unknown environments using evolutionary techniques. In addition, we integrate the exploration and planning process in a unified framework using multi agent system. As a proof of success, we have developed extensive simulations with realist...

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenera...

Due to the emergence of embedded applications in image and video processing, communication and cryptography, improvement of pictorial information for better human perception like de-blurring, denoising in several fields such as satellite imaging, medical imaging, mobile applications etc. are gaining importance for renewed research. Behind such developments, the primary responsibility lies with ...

This study tackles the task of swarm robotics, where robots explore environment to detect targets. When a robot detects target, must be connected with base station via intermediate relay for wireless communication. Our previous results confirmed that Lévy flight outperformed usual random walk exploration strategy in an indoor environment. paper investigated search performance crawler on target ...

Background:Shigella flexneri is a gram negative bacteria that causes the infectious disease "shigellosis." S. flexneri is responsible for developing diarrhea, fever, and stomach cramps in human. Antibiotics are mostly given to patients infected with shigella. Resistance to antibiotics can hinder its treatment significantly. Upon identification of essential therapeutic targets, vaccine and drug ...

The fast mineral exploration system with remote sensing is a brand new exploration system of recognition, identification, analysis and prediction. It takes metallogenic materials as the detection targets, uses the spectrum measuring technique as detection means and takes the spatial and temporal sequence of mineralization and alteration information as an evaluation basis. It develops and improv...