Objective(s):Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immunity. It is an incurable disease that affects millions of people worldwide. Developing new strategies for the treatment of colitis has been a major challenge. Here, we report the effect of calycosin, a plant-derived flavonoid, in successfully managing colitis in murine model. Material and Methods:...

The prevalence of ulcerative colitis, one the inflammatory bowel diseases, has been increasing worldwide. Though fatty diet leads to development only little is known about separate and combined effects different fat compositions intermittent fasting, preventative dietary changes on experimental colitis. In this study, we investigated effect feeding type frequency inflammation Five groups, each ...

BACKGROUND Ulcerative colitis (UC) promotes cancer, and can be ameliorated by early appendicectomy for appendicitis. The aim of the study was to explore the effect of appendicectomy on colitis and colonic neoplasia in an animal model of colitis and a cohort of patients with UC. METHODS Five-week old IL10/Nox1(DKO) mice with nascent colitis and 8-week-old IL10/Nox1(DKO) mice with established c...

UNLABELLED Experimental colitis induced by acetic acid has been used extensively as a model for intestinal inflammatory disease. Colonic tissue lesions of intestinal inflammatory disease patients seem to be related to the increased local production of pro-inflammatory cytokines (IL-1, IL-6, TNF-alpha, and IFN-gamma). PURPOSE To assess the cytokine expression pattern identified through immunoh...

spasmolytic, antioxidant, anti-inflammatory and immuno-modulatory properties of ginger (rhizome of zingiber officinale roscoe) suggest that it may has beneficial effects on inflammatory bowel diseases. in the present study, the effect of this herbal extract on a model of acute colitis was evaluated. ginger hydroalcoholic extract with doses of 150, 350, 700 mg/kg, prednisolone (2 mg/kg), or vehi...

Resident bacteria are incriminated in the pathogenesis of experimental colitis and inflammatory bowel diseases. We investigated the relative roles of various enteric bacteria populations in the induction and perpetuation of experimental colitis. HLA-B27 transgenic rats received antibiotics (ciprofloxacin, metronidazole, or vancomycin-imipenem) in drinking water or water alone in either preventi...