The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell ...

Since melatonin was first isolated in 1958 up to the last few years, this substance was considered a hormone exclusive to the pineal gland. Although melatonin has lately been identified in a large number of extrapineal sites, its potential biological actions have not yet been studied. This paper shows that human lymphocyte-synthesized melatonin plays a crucial role modulating IL-2/IL-2 receptor...

background: damage to spermatogenic and fertility disorders are among major side effects of chemotography drugs such as busulfan. to reduce the side effects of these drugs different methods such as protecting and fixing germinal cell epithelium, while employing chemotherapy are used. the aim of this study was to investigate the effect of exogenous melatonin on the treatment of oligospermic in s...

Melatonin is a new plant hormone that plays an important role in stress tolerance. For investigation the effect of exogenous application of melatonin on salt tolerance in rosemary (Rosmarinus officinalis L.), a factorial experiment was conducted in a completely randomized design with three replications. The first factor was melatonin (50, 100 µM) and the second factor was salinity stress (6, 9,...

background: it is important to protect oocytes and embryos from oxidative stress in the culture medium. melatonin has been shown to be a direct free radical scavenger. objective: effect of melatonin during in vitro oocyte maturation, fertilization and embryo development of mouse oocytes was evaluated. materials and methods: oocytes from supper-ovulated mouse were divided to two groups: cumulus ...

Melatonin (MT) is involved in physiological processes plants under abiotic stress. In this study, we investigated the effects of melatonin on maize photosynthetic and antioxidant capacities salinity Our findings indicated stress significantly inhibited growth. However, exogenous MT promoted growth capacity. Superoxide dismutase, peroxidase, catalase increased by 138.8, 38.7, 32.0%, respectively...

background: it has been shown that dietary restriction in the form of every other day fasting (eodf) has neuroprotective effects. the mechanisms of these effects are unknown yet. recently, it has claimed that dietary restriction can reset circadian and regulate irregular rhythms. previous studies have demonstrated that dietary restriction can change melatonin production and secretion. since mel...

objective(s): there are few reports have demonstrated the effect of a change-in-light experience on the structure and function of hippocampus. a change-in-light experience also affects the circadian pattern of melatonin secretion. this study aimed to investigate developmental effect of exogenous melatonin on synaptic plasticity of hippocampus of light deprived rats. materials and methods: the e...

Citation: Liang D, Shen Y, Ni Z, Wang Q, Lei Z, Xu N, Deng Q, Lin L, Wang J, Lv X and Xia H (2018) Exogenous Melatonin Application Delays Senescence of Kiwifruit Leaves by Regulating the Antioxidant Capacity and Biosynthesis of Flavonoids. Front. Plant Sci. 9:426. doi: 10.3389/fpls.2018.00426 Exogenous Melatonin Application Delays Senescence of Kiwifruit Leaves by Regulating the Antioxidant Cap...