Automatic foci with membrane potentials in the range characterized by depolarization-induced automaticity exhibit entrance block. The present study demonstrates a role of variable entrance and exit block in arrhythmogenesis. We studied canine interventricular septa with the right bundle branch exposed, isolated false tendons and isolated feline papillary muscle using standard microelectrode tec...

In this paper we investigate the stationary profiles of a nonlinear Fokker-Planck equation with small diffusion and in- outflow boundary conditions. We consider corridors bottleneck whose width has global nondegenerate minimum in interior. limit are obtained constructively by using methods from geometric singular perturbation theory (GSPT). identify three main types corresponding to: (i) high d...

We study an open-chain totally asymmetric exclusion process (TASEP) with stochastic gates present at the two boundaries. The gating dynamics has been modeled keeping the physical system of ion-channel gating in mind. These gates can randomly switch between an open state and a closed state. In the open state, the gates are highly permeable such that any particle arriving at the gate immediately ...