cyclophosphamide (cp) is a mustard alkylating agent used in the treatment of a number of neoplastic diseases and as an immunosuppressant for the prevention of xenograft rejection. there are many reports that the teratogenic effects of cyclophosphamide can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. also, there is some evidence that l-carnitine...

Mutant curly-tail mice are genetically predisposed to produce offspring with neural tube defects. Estimation of alpha-fetoprotein in the amniotic fluid of fetuses of these mutants has shown that the levels are raised in fetuses with exencephaly and open spina bifida. This suggests that these mice are a valid model for studies of the aetiology and genesis of neural tube defects in man.

Cyclophosphamide (CP) is a mustard alkylating agent used in the treatment of a number of neoplastic diseases and as an immunosuppressant for the prevention of xenograft rejection. There are many reports that the teratogenic effects of cyclophosphamide can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Also, there is some evidence that L-carnitine...

Pregnant rodents were fed concentrations of a mixture of polybrominated biphenyls (Firemaster BP-6) during the pregnancy. The material appears to be weakly teratogenic, causing exencephaly and cleft palate in mice. Decreasing birth weight with increasing dosage of the material was seen in both mice and rats. Nonpregnant mice fed 1000 ppm Firemaster BP-6 for 11 days had a marked increase in live...

Introduction Amnion rupture in early pregnancy results in severe anomalies such as anencephaly, encephalocoele, exencephaly, acrania, facial clefts and absence of limbs (1,2). Most affected fetuses abort in the second trimester, are stillborn or die soon after birth (1,3).We report an infant with amnion rupture sequence, who survived for 9 weeks after birth. A Medline search failed to reveal do...