The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Methocel K100M. In vitro dissolution studies were ...

In the present study, gastro retentive microparticulate systems of ranitidine HCl were prepared by spray drying. Biocompatible polymers like Eudragit RS100, Eudragit RL100 were used in the formulation. Factorial design (2) was employed by taking drug to polymer ratio and polymer to polymer ratio as factors. FTIR and DSC studies showed that Ranitidine HCl and excipients are compatible. Scanning ...

Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Furosemide a loop diuretic belonging to Biopharmaceutical Classification System (BCS) Class IV, has very poor water solubility. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, ...

Abstract Background The goal of the current study was to create, improve, and test a transdermal patch loaded with primaquine for treatment malaria. Several ingredients were used create patch. For choosing polymers, placebo patches created. optimization polymer ratios development testing their impact on tensile strength, in vitro drug release, permeation, ex vivo permeation employed response su...

Recent research on idealizing drug delivery systems which is progressing at a prodigious rate, aims at the development of drug delivery systems with maximum therapeutic benefits of drug delivery thus resulting in safe and effective management of diseases. In the present study Nanoparticlulate drug delivery system for Cyclosporine was developed, that would overcome the therapeutic risks of conve...

Colon-targeted drug delivery systems (CTDDSs) could be useful for local treatment of inflammatory bowel diseases (IBDs). In this study, various interpolyelectrolyte complexes (IPECs), formed between Eudragit RL100 (EL) and chitosan (CS), by nonstoichiometric method, and tablets based on the IPECs, prepared by wet granulation, were evaluated as potential oral CTDDSs for ibuprofen (IBF). Results ...

Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulos...