For both type 1 and type 2 diabetes mellitus, the rates have been increasing in the United States and elsewhere; rates vary widely by country, and genetic factors account for less than half of new cases. These observations suggest environmental factors cause both type 1 and type 2 diabetes. Occupational exposures have been associated with increased risk of diabetes. In addition, recent data sug...

The detailed analysis of mammary neoplasia in inbred mice has disclosed 3 important etiologic factors, compris ing, as stated in Bittner's 3-factor hypothesis, a genetic factor, a hormonal factor, and a milk-borne tumor agent with the properties of a virus and now usually called the milk agent or the Bittner virus. Within certain limits, an excess of one factor can compensate for deficiency in ...

T h e main objective of this paper is to evaluate the significance of certain etiologic factors in carcinoma of the penis. The factors considered are venereal disease, circumcision, and the age and race of the patients. A second objective is to illustrate the use of control groups in a statistical study. The use of controls is routine in experimental work and every experimental group is checked...

Soft tissue sarcomas account for about 1% of all malignancies. The increase in incidence of soft tissue sarcomas during the recent decades may predominantly be attributed to AIDS-related Kaposi's sarcoma; when this tumor is excluded, conclusive evidence for an age-adjusted increase is lacking. Beside the well investigated role of the human immunodeficiency virus 1 (HIV-1) and the human herpesvi...

Hyperlipidemia is a well-recognized complication of renal transplantation. In long-term survivors of renal transplantation, cardiovascular disease accounts for the majority of patient deaths. In the cyclosporine era, cardiovascular disease has surpassed infection as the number one cause of death. Risk factors in the transplant population for hyperlipidemia include age, male sex, diabetes, predn...

Disturbances of speech comprehension were analyzed in a prospective study of 97 children, aged from 23 to 77 months. Pregnancy, birth and early psychomotor development were normal for all the children and no focus of neurological deficit was found. A tonal audiometer did not detect any auditory disturbances, and psychological testing with non-verbal tests showed normal mental functioning for th...