A recent editorial in the Archives assigned the primary pathogenesis of infantile esotropia to the visual cortex. This analysis addresses the limitations of this timeworn view and advances the perspective that infantile esotropia is a cortico-mesencephalic-cerebellar disorder wherein binocular cortical maldevelopment permits atavistic subcortical visual pathways to remain operational. This inte...

PURPOSE To investigate the clinical course in patients who underwent surgical correction of consecutive esotropia. METHODS The medical records of 13 patients who underwent surgical correction of consecutive esotropia were reviewed retrospectively. The authors investigated the deviation and surgical method at the time of exotropia surgery. During the follow up period, the authors also studied ...

PURPOSE The aims of this study were to examine the distribution of refractive errors and clinical characteristics of strabismus in Korean patients with Down's syndrome. METHODS A total of 41 Korean patients with Down's syndrome were screened for strabismus and refractive errors in 2009. RESULTS A total of 41 patients with an average age of 11.9 years (range, 2 to 36 years) were screened. Ei...

Unilateral or bilateral lateral rectus resection is commonly performed for the correction of residual esotropia, but few results have been reported. Twenty-eight patients with residual esotropia underwent bilateral lateral rectus (BLR) resection. Six months after operation (n = 25), there were 17 (68%) successful cases, 7 (28%) cases of undercorrection, and 1 (4%) case of overcorrection. The su...

PURPOSE Human infants at greatest risk for esotropia are those who suffer cerebral insults that could decorrelate signals from the 2 eyes during an early critical period of binocular, visuomotor development. The author reared normal infant monkeys, under conditions of binocular decorrelation, to determine if this alone was sufficient to cause esotropia and associated behavioral as well as neuro...

PURPOSE To elucidate the genetic or environmental background for clinical features in the three major types of comitant strabismus. METHODS Interview based on a questionnaire asking background factors such as family history of strabismus and abnormalities in pregnancy and delivery was conducted with 101 consecutive patients with infantile esotropia (5-180 months of age), 83 with accommodative...

PURPOSE Esotropia is a feature of albinism. Amongst esotropic patients there may be mild unrecognised albinos. Oculocutaneous albinism shares several clinical features with congenital esotropia. It is well known that mammals with oculocutaneous albinism have misrouted retinal ganglion cell axons, most likely caused by the absence of melanin or DOPA during development. We investigated the hypoth...

AIM Recent studies suggest that Asian strabismus patterns are different from those in the West. This study aims to determine the profile of children with comitant horizontal strabismus in Singapore. METHOD 682 children aged <or=16 years presenting with strabismus for the first time between 2000 and 2002 were included in this study. The type and size of the squint, visual acuity, refractive er...

PURPOSE To report refractive and surgical outcomes in a cohort of children with accommodative esotropia. DESIGN Retrospective population-based cohort. PARTICIPANTS All pediatric patients (<19 years) diagnosed with accommodative esotropia in Olmsted County, Minnesota, from January 1, 1975, to December 31, 1994. METHODS Medical records identified by the Rochester Epidemiology Project were r...