BACKGROUND Although pedophilia is of high public concern, little is known about underlying neural mechanisms. Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles. METHODS Thirteen pedophilic patients and 14 health...

Some authors have speculated that the cognitive component (P3) of the Event-Related Potential (ERP) can function as a psychophysiological measure of sexual interest. The aim of this study was to determine if the P3 ERP component in a workload task can be used as a specific and objective measure of sexual motivation by comparing the neurophysiologic response to stimuli of motivational relevance ...

It was demonstrated by Richardson in 1936 (1) that uracil and guanine were essential for the growth of certain bacteria. Later several investigators found that purines and pyrimidines and corresponding nucleotides are of importance for the metabolism of different microorganisms. Snell and Mitchell (2) established the fact that guanine, adenine, uracil, and thymine may be limiting factors of gro...

Desire for amputation of a healthy limb has usually been regarded as a paraphilia (apotemnophilia), but some researchers propose that it may be a disorder of identity, similar to Gender Identity Disorder (GID) or transsexualism. Similarities between the desire for limb amputation and nonhomosexual male-to-female (MtF) transsexualism include profound dissatisfaction with embodiment, related para...

The habituation of genital and subjective sexual arousal in women was assessed. In a first experiment 32 women were randomly assigned to either a constant stimulus condition in which subjects were exposed to the same erotic slide on repeated trials within one session, or to a varied stimuli condition in which subjects were exposed to various erotic slides. A second experiment assessed habituati...

The ‘identity’ of eighteenth century England has provoked much debate, with discussion often turning on the relative vibrancy of features displaying ‘modernity’ or the lingering aspects of an ‘ancien regime’.3 The polite vision of Langford and the Enlightened, liberatedworld seen by Porter share an emphasis on the eighteenth century looking forward. Yet these are contrasting pictures: on the on...

Biochemical proccr are described which have been found useful in the s tudy of normal pyrimidine Inctabolism as influenced by 6-azm~ridine. One technic involves the t rapping of radioactive carbon dioxide liberated from erotic acid-7-C ~4 during the conversion of this compound to uridine nucleotides by isolated leukocytes in vitro. The susceptibility of this conversion to inhibition by azauridi...