Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER-mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understood. Here we show that in yeast, the ER-mitochondria tethering complex, ERMES, and the highly conserved Miro GTPase, Gem1, are spatially and functiona...

Emerging evidence suggests that contact sites between different organelles form central hubs in the coordination of cellular physiology. Although recent work has emphasized the crucial role of the endoplasmic reticulum in interorganellar crosstalk, the cooperative behavior of other organelles is largely unexplored. Here, we identify a contact site named vCLAMP (vacuole and mitochondria patch) t...

The local mass-transfer rate was investigated along the bottom wall of two-dimensional cavities of nominally rectangular shape, 100 mm wide, and aspect ratio (depth/width) 0.5. Experimental measurements were made by an electrochemical limiting current technique based on reduction of K3Fe(CN)6 at gold ultramicroelectrodes, each 10 mm wide and spaced 1 mm apart. Experiments were carried out in th...

Mitochondrial membrane biogenesis and lipid metabolism require phospholipid transfer from the endoplasmic reticulum (ER) to mitochondria. Transfer is thought to occur at regions of close contact of these organelles and to be nonvesicular, but the mechanism is not known. Here we used a novel genetic screen in S. cerevisiae to identify mutants with defects in lipid exchange between the ER and mit...

Laetitia Gauvin1,∗, Annick Vignes, Jean-Pierre Nadal 1. Laboratoire de Physique Statistique (LPS, UMR 8550 CNRS-ENS-UPMC-Univ. Paris Diderot), Ecole Normale Supérieure, Paris, France 2. Equipe de Recherche sur les Marchés, l’Emploi et la Simulation (ERMES, EA 4441 CNRS-Paris II), University Paris II Panthéon-Assas, Paris, France 3. Centre d’Analyse et de Mathématique Sociales (CAMS, UMR 8557 CN...

Son y?llarda sosyal, ekonomik ve teknolojik geli?meler insanlar?n yeni yerler kültürleri ke?fetme tan?ma iste?ini art?rm??t?r. Seyahat etme tatil yapma fikri paket tur sözle?melerinin yayg?nla?mas?na neden olmu?tur. Paket düzenleyicileri veya arac?lar? taraf?ndan ula?t?rma, konaklama ba?ka turizm hizmetlerinden en az ikisinin birlikte, her ?eyin dâhil oldu?u fiyatla sat?ld??? sat?m?n?n vaat edi...

within the context of climate change, water scarcity is the major constraint to the viability of many crops. thus, it is necessary to develop strategies for sustainable water management, and introduce alternative crops to sustain the viability of agro-ecosystems. the main objective of this work was to assess the performance of hemp (cannabis sativa l.) subjected to different plant densities and...

H ERMES (Harmonised Education in Respiratory Medicine for European Specialists) was launched in 2005 by the European Respiratory Society (ERS), with the aim of harmonising education and training in respiratory medicine. The first deliverable component, a core syllabus representing the content of required knowledge in our specialty [1], will be released at the 2006 ERS Annual Congress in Munich....

Mitochondrial membrane phospholipid composition affects mitochondrial function by influencing the assembly of the mitochondrial respiratory chain (MRC) complexes into supercomplexes. For example, the loss of cardiolipin (CL), a signature non-bilayer-forming phospholipid of mitochondria, results in disruption of MRC supercomplexes. However, the functions of the most abundant mitochondrial phosph...