Abst r a ct This paper ut ilises t he Crit ical Syst em s Heur ist ics (CSH) fram ew ork dev eloped by Werner Ulrich t o crit ically consider t he st akeholder s and design goals t hat should be consider ed as r elevant by researchers conducing Design Science Resear ch (DSR). CSH provides a philosophically and t heoret ically gr ounded fram ework and m eans for crit ical considerat ion of t he ...

Obstructive sleep apnea (OSA) is a common disorder, characterized by cyclic cessation of airflow for 10 seconds or more. There is growing awareness that OSA is related to the development and progression of cardiovascular disease. However, only a few studies have associated OSA directly to major cardiovascular events. The aim of this study was to evaluate the relationship between OSA and cardiov...

onion is one of the important strategic crop plants of a highly valuable nutritional food source, consumed almost around the whole world. thus, the genetically oriented studies around the plant are valuable and inevitable. for a following of these studies, some onion masses from various regions throughout iran, including: kashan-white, azarshahr-red, isfahan-dorcheh, ghom-white, zanjan-gholighe...

To see a patient and recognise amyotrophic lateral sclerosis as the underlying cause of progressive, painless paralysis without sensory symptoms has been deemed easy, and indeed it is for physicians seeing patients with motor neuron disease on a regular basis. Answering patients’ questions of ‘How bad is it? What will happen to me? How long do I have?’ is however no mean feat; these questions i...

We have arbitrarily chosen our recommended W.-K. Chan reduced dosage of thrombolytic therapy as few T.-F. Chan studies address this issue. The largest study was by Division of Cardiology Goldhaber et al.6 comparing reduced rtPA bolus Department of Medicine & Geriatrics (0.6 mg/kg/15 min, maximum 50 mg) and rtPA infuUnited Christian Hospital sion (100 mg over 2 h) in 87 patients, a double-blind ...

471 should be recruited. This in fact means a suffi­ cient amount of money that is needed to orga­ nize such a study. On the one hand, this effec­ tively limits the numbers of single nephrology centers to think about, but on the other hand, it promotes an international cooperation, which in the last years have yielded numerous break­ through results.3-5,7 The next group consists of the transcri...

The vegetation and selected ground water characteristics of Silica Sand Quarry Bog, a pioneer bog forming in an abandoned sandstone quarry, were examined. After 70 years of development the bog mat measures 0.75 km in diameter and contains 35 species of vascular plants and 5 species of Sphagnum. Six species of vascular plants from the bog are on Ohio's rare plant list. The herbaceous layer is th...

The DNA polymerase and nuclease activities of bacteriophage T4 DNA polymerase mutants are discussed in the context of the crystal structure of the closely related bacteriophage RB69 DNA polymerase. IT is fitting that this issue of Genetics honoring Jan erly skeptical about my observation, understood from Drake, who has made so many outstanding contrimy questions that I was not a geneticist, and...

M technology plays an essential role in the timely diagnosis and manage­ ment of many conditions. Lately, however, it’s become equally well known for its low­value uses and as the single largest source of per capita radiation exposure. Imaging is by far the most com­ mon service on the lists of un­ necessary tests and procedures of the Choosing Wisely campaign, and an estimated 20 to 50% of ima...

N otre Dame freshm an, Tom H am ilton , announced the for­ m ation o f the S tuden ts for Biafran Relief, a national o rgan­ ization designed to funnel funds to th e Nigerian Red Cross, w hich is conducting relief opera tions in Biafra. “ We are appalled by the con ­ d itions in the form er Biafran enclave. It is o u r objective to help alleviate these problem s. We hope th a t everybody will w...