Between 2006 and 2008, 5 adult horses hailing from South Germany (4/5 cases) and Austria (1/5) with different case histories but similar lung lesions were investigated at the Faculty of Veterinary Medicine of the Ludwig-Maximilians-University in Munich. Anamnesis included amongst others ongoing respiratory symptoms, weight loss, and poor body condition. Pathological examination of the lungs rev...

The complete DNA sequence of equine herpesvirus-4 (EHV-4) strain NS80567 was determined. The genome is 145597 bp in size and consists of a long unique region (UL, 112398 bp) flanked by a short inverted repeat (TRL/IRL, 27 bp) linked to a short unique region (Us, 12789 bp) flanked by a substantial inverted repeat (TRs/IRs, 10178 bp). EHV-4 is predicted to contain 76 different genes; three of the...

i Acknowledgements iii Chapter 1 General introduction 1 Chapter 2 Literature review 5 Chapter 3 A nested multiplex PCR for the detection and differentiation of equine herpesvirus 1, 2, 4 and 5. 73 Chapter 4 The prevalence of equine herpesviruses in clinically normal horses 90 Chapter 5 The association of equine herpesviruses with respiratory disease and poor performance in adult horses in Weste...

Infection of a human lymphoblastoid cell line (Jijoye line derived from a Burkitt lymphoma which contains Epstein-Barr virus) with equine herpesvirus 1, maintained and observed for 53 days, was characterized by the continuous production of infectious extracellular and intracellular virus. Maximum virus production correlated with active cell multiplication. Less than 15% of the cells possessed v...

BACKGROUND To date the influence of herpesviruses on the development of equine ocular diseases has not been clearly determined. OBJECTIVE The purpose of this study was to illustrate the course of equine ocular findings over a period of 18 months at 6 month intervals, in correlation with the results of herpesvirus detection. METHODS 266 Lipizzaners in 3 federal states of Austria underwent co...

the herpesviruses infections in equides are caused by five different serotypes of viruses, belonging to family herpesviridae. the goal of this study was to conduct a seroepidemiological investigation of equine herpesvirus type 1 (ehv-1) and type 4 (ehv-4) in horses and donkeys raised in two provinces and their villages in northeastern turkey. a total of 666 samples from 423 horses and 243 donke...