UNLABELLED Histopathological diagnosis of oral lichen planus is not easy since some cases of epithelial dysplasia may present traits which are very similar to those from lichen planus. AIM to compare cell alterations which suggest malignancy present in oral lichen planus with those from epithelial dysplasia. MATERIAL AND METHODS histological cross-sections of oral lichen planus and dysplasi...

Background:-Mitotic figures refer to the various phases of mitosis which are well appreciated in tissue sections.They act as prognostic indicators in oral epithelial dysplasia. Aim:-To compare and evaluate the mitotic figures in oral epithelial dysplasia using H & E and Toluidine blue stains. Objective:-Using H&E, Toluidine blue stains in the identification and counting of mitotic figures in di...

Oral epithelial dysplasia is thought to be a precursor state of carcinogenesis and may harbor gene alterations. Recently, it was reported that gene editing enzyme, activation-induced cytidine deaminase (AID), is expressed in precursor and cancer epithelial cells during carcinogenesis associated with chronic inflammation/infection and that this enzyme induces mutation of tumor-suppressor genes. ...

The concept of a two-step process of cancer development in the oral mucosa, i.e., the initial presence of a precursor subsequently developing into cancer, is well-established. Oral leukoplakia is the best-known precursor lesion. The evidence that oral leukoplakias are pre-malignant is mainly derived from follow-up studies showing that between < 1 and 18% of oral pre-malignant lesions will devel...

The oral lichen planus constitutes one of the white injuries more frequent than they appear in the oral mucosa and it is considered that it has certain risk of malignant transformation, recognising the presence of epithelial dysplasia like predicting histological of these changes. The occurrence of epithelial dysplasia, as a possible precursor of malignant transformation, has been studied scarc...

PURPOSE We determined whether patients with bladder cancers accompanied by carcinoma in situ (CIS) or epithelial dysplasia carry a poor prognosis. MATERIALS AND METHODS The resected bladders from 57 patients with a bladder cancer were step-sectioned. The stained specimens underwent microscopic examination and the extent of CIS and epithelial dysplasia was mapped out. The 57 patients were foll...

Oral squamous cell carcinoma (OSCC) is usually preceded by detectable mucosal changes, as leukoplakias and erythroplakia. Histologically, these lesions can range from hyperkeratosis and acanthosis to epithelial dysplasia and even OSCC. The aim of this study was to investigate the proliferative activity, using AgNORs quantification proteins, in low- and high-risk oral epithelial dysplasia, OSCC,...

BACKGROUND Routine staining procedures often pose a problem in differentiating a mitotic cell from an apoptotic cell, deteriorating the reliability of histology grading. Although various new methods have been recommended for identifying mitotic figures (MFs) in tissues, the time factor and cost makes them less feasible. Thus, an attempt was made to evaluate the efficacy of crystal violet and Fe...

The potential for malignant transformation of oral lichen planus is still controversial. The expression of proteins related to cell proliferation and apoptosis in oral lichen planus and epithelial dysplasia was analyzed to evaluate the true potential for malignant transformation of this disease. Twenty-four cases of each lesion were subjected to the streptoavidin-biotin technique for identifyin...

Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA2 attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA2 alone can lead to malignant transformation in the intestinal tract has not been studied. In this study, we expressed human LPA2 in intestinal e...