BACKGROUND A high incidence of epileptiform activity in the electroencephalogram (EEG) was reported in children undergoing mask induction of anaesthesia with administration of high doses of sevoflurane for 5 minutes and longer. This study was performed to investigate whether reducing the time of exposure to a high inhaled sevoflurane concentration would affect the incidence of epileptiform EEG ...

The aim of this study was to investigate the presence of apparent non-epileptiform activity arising in the same brain area as epileptiform activity in the EEG of paediatric patients with focal epilepsy. The EEG from eight patients was analyzed by an automated method which detects epochs with a single underlying source having a dipolar potential distribution. The EEG with the highlighted detecti...

OBJECTIVE Although benzodiazepines and other GABAA receptors allosteric modulators are used to treat neonatal seizures, their efficacy may derive from actions on subcortical structures. Side effects of benzodiazepines in nonseizing human neonates include myoclonus, seizures, and abnormal movements. Excitatory actions of GABA may underlie both side effects and reduced anticonvulsant activity of ...

OBJECTIVE The aim of this study was to investigate the presence and characteristics of apparent non-epileptiform activity arising in the same brain area as epileptiform activity in the EEG of paediatric patients with focal epilepsy. METHODS The EEG from eight patients was analysed by an automated method which detects epochs with a single underlying source having a dipolar potential distributi...

objective: curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. the present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. materials and methods: in urethane-anesthetized rats, epileptiform activity was induced by intraco...

The spread of epileptiform activity was monitored in guinea-pig neocortical slices by the use of a voltage-sensitive dye (RH795) and a fast optical recording technique. Epileptiform activity induced by bicuculline methiodide (10-20 microM) and single-pulse stimulation spread from the stimulation site in layer I or in the white matter across most of the slice. Different lesions were made in the ...

It has been reported that the inhibitory postsynaptic potential (IPSP) is abolished before the excitatory postsynaptic potential (EPSP) when the extracellular concentration of Ca(2+) ([Ca(2+)](o)) is removed gradually in hippocampal slices. However, the low-Ca(2+) nonsynaptic epileptiform activity does not appear until the [Ca(2+)](o) is decreased to a level sufficient to depress the excitatory...

Neuronal hyperexcitability plays an important role in epileptogenesis. Conditions of low extracellular calcium (Ca) or magnesium (Mg) can induce hyperexcitability and epileptiform activity with unclear mechanisms. Transient receptor potential canonical type 3 (TRPC3) channels play a pivotal role in neuronal excitability and are activated in low-Ca and/or low-Mg conditions to depolarize neurons....