نتایج جستجو برای: epidermal growth factor receptor

تعداد نتایج: 1911087  

2001
Jose A. Fernandez-Pol

A monoclonal antibody to the epidermal growth factor (EGF) receptor of A431 cells, denoted 2Dl-IgM, was generated after fusion of immunized BALB/c mouse spleen cells with SpZ/O-Ag14 myeloma cells, Specific binding of 2D1-IgM to the A431 cell-surface receptor for EGF was demonstrated by indirect immunofluorescence, immunoprecipitation, and immunoblot analysis. Scatchard analysis of lz6I-EGF bi...

Journal: :Clinical science 1991
J Jankowski R McMenemin D Hopwood J Penston K G Wormsley

1. In order to assess potential abnormalities in the control of mucosal proliferation, 30 patients with Barrett's oesophagus were studied in order to evaluate the presence and distribution of epidermal growth factor, transforming growth factor-alpha and epidermal growth factor receptor to determine the Ki-67 labelling index in the affected oesophageal mucosa. Serial sections were analysed immun...

Journal: :Cancer research 1988
J Ro S M North G E Gallick G N Hortobagyi J U Gutterman M Blick

We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to the epidermal growth factor receptor that the receptor protein product of this g...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Dawn Mattoon Peter Klein Mark A Lemmon Irit Lax Joseph Schlessinger

Quantitative epidermal growth factor (EGF)-binding experiments have shown that the EGF-receptor (EGFR) is displayed on the surface of intact cells in two forms, a minority of high-affinity and a majority of low-affinity EGFRs. On the basis of the three-dimensional structure of the extracellular ligand binding domain of the EGFR, it was proposed that the intramolecularly tethered and autoinhibit...

Journal: :iranian red crescent medical journal 0
sara pouranvari department of biology, science and research branch, islamic azad university, tehran, ir iran firouz ebrahimi biology research center, basic sciences faculty, imam hossein university (ihu), tehran, ir iran; biology research center, basic sciences faculty, imam hossein university (ihu), tehran, ir iran. tel: +98-9123068466, fax: +98-02177104934 gholamreza javadi department of biology, science and research branch, islamic azad university, tehran, ir iran bozorgmehr maddah department of chemistry, basic sciences faculty, imam hossein university (ihu), tehran, ir iran

background epidermal growth factor (egf) plays a fundamental role in the healing of wounds relating to skin damage, the cornea, and the gastrointestinal tract. objectives the aim of this study is the cloning, expression, and purification of recombinant human egf (rhegf), and an assessment of its activity. materials and methods in the present experimental study, a synthetic pet28a (+) -hegf cons...

2016
Akira Inoue Kazushi Yoshida Satoshi Morita Fumio Imamura Takashi Seto Isamu Okamoto Kazuhiko Nakagawa Nobuyuki Yamamoto Satoshi Muto Masahiro Fukuoka

BACKGROUND The Japan Guidelines of Lung Cancer Therapy recommend epidermal growth factor receptor-tyrosine kinase inhibitors as a first-line therapy for advanced/recurrent non-small cell lung cancer patients with epidermal growth factor receptor mutation. Although survival periods in recent reports of epidermal growth factor receptor-tyrosine kinase inhibitor treatment have been getting longer,...

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