AIM The aim of the study was to examine whether ephedrine and phenylephrine were different in their efficacy for managing maternal hypotension and their effect of adverse maternal and neonatal outcome. METHODS A double-blind randomized controlled study in healthy pregnant women ASA physical status 2, which underwent elective caesarian delivery under spinal anesthesia. Patients were randomized...

BACKGROUND In our routine practice, we observed a reduced incidence of fetal acidosis (umbilical artery pH < 7.20) at cesarean delivery during spinal anesthesia when a combination of phenylephrine and ephedrine was used as first line vasopressor therapy, compared with using ephedrine alone. METHODS The study was randomized and double blind. It compared phenylephrine 100 microg/ml (phenylephri...

Corresponding author: Young-Tae Jeon, M.D., Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 300, Gumi-dong, Bundang-gu, Seongnam 463-802, Korea. Tel: 82-31-787-7499, Fax: 82-31-787-4063, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommon...

The sale of ephedrine, one of the precursors of methamphetamine, is strictly controlled and monitored in various countries to prevent the production of illicit methamphetamine. There are three kinds of production scheme for ephedrine manufacture, and it is very useful for precursor control to investigate the origin of ephedrine used for the synthesis of illicit methamphetamine. By means of stab...

BACKGROUND Use of ephedrine in obstetric patients is associated with depression of fetal acid-base status. The authors hypothesized that the mechanism underlying this is transfer of ephedrine across the placenta and stimulation of metabolism in the fetus. METHODS A total of 104 women having elective Cesarean delivery under spinal anesthesia randomly received infusion of phenylephrine (100 mic...

Title of Thesis: BIOACTIVITY OF EPHEDRA: INTEGRATING CYTOTOXICITY ASSESSMENT WITH REAL-TIME BIOSENSING Kazuko Fukushima, Master of Science, 2004 Thesis Directed By: Dr. Y. Martin Lo, Department of Nutrition and Food Science Ephedrine-type alkaloids (ETA) are major active ingredients of Ephedra, a traditional Chinese medicinal herb used to treat asthma and nasal congestion. Until recently, large...

BACKGROUND Unilateral spinal anesthesia is used to limit the spread of block. The aim of the present study was to compare hemodynamic changes and complications in unilateral spinal anesthesia and epidural anesthesia below the T10 sensory level in unilateral surgeries. MATERIALS AND METHODS In this double-blind randomized clinical trial in total 120 patients were randomly divided into a unilat...

Background: In most of the obstetric patients undergoing caesarean section, spinal anaesthesia is the most accepted approach. It provides a rapid, intense, definite and better sensory and motor blockade. In spite of this, eighty per cent of patients experience hypotension after spinal anaesthesia. The use of vasopressors (Phenylephrine and Ephedrine) is the mainstay of treatment for hypotension...

Ephedrine, a natural alkaloid from plants of the genus Ephedra, has a chemical structure similar to catecholamines. It is well established that catecholamines (adraneline, noradrenaline and dopamine) cause genotoxic and mutagenic effects. Therefore, the objectives of this investigation were to examine weather ephedrine can exhibit genotoxic effects on isolated human lymphocytes in the Comet ass...

The aim of this study was to evaluate the antioxidant activity, screening the phytogenic chemical compounds, and to assess the alkaloids present in the E. intermedia to prove its uses in Pakistani folk medicines for the treatment of asthma and bronchitis. Antioxidant activity was analyzed by using 2,2-diphenyl-1-picryl-hydrazyl-hydrate assay. Standard methods were used for the identification of...