Aims: Obesity is associated with cardiovascular disease. Today, changing childhood lifestyle may affect on cardiovascular diseases factors. The goal of this research was to determine the evaluation of changes in lipid profiles, insulin resistance and serum FGF21 following three types of exercise training in sedentary obese children. Materials and Methods: Sixty obese boys 8-12 years old with z...

Background & objectives: Diabetes mellitus, as a metabolic disease, is associated with impaired insulin resistance index and cardiovascular risk factors. The purpose of this study was to investigate the effect of a concurrent exercise and Ginger supplementation on cardiorespiratory endurance, body composition, and insulin resistance index in obese women with type 2 diabetes. Methods: 60 women ...

BACKGROUND Although several studies have investigated gender differences in the substrate and endocrine responses during and following endurance exercise, few have studied sex differences during a more prolonged recovery period post endurance exercise. The purpose of this study was to compare and characterize the endocrine and substrate profiles of trained male and female adult runners during t...

R egular exercise represents an effective strategy to prevent and/or treat type 2 diabetes (1,2). However, the clinical benefits of exercise intervention in a vastly expanding group of long-standing insulin-treated type 2 diabetic patients with comorbidities are less evident. As these patients generally experience muscle weakness (3–6), cardiovascular comorbidities (7–10), and/or exercise intol...

One hallmark of the insulin-resistant state of prediabetes and overt type 2 diabetes is an impaired ability of insulin to activate glucose transport in skeletal muscle, due to defects in IRS-1-dependent signaling. An emerging body of evidence indicates that one potential factor in the multifactorial etiology of skeletal muscle insulin resistance is oxidative stress, an imbalance between the cel...

Intramuscular triglyceride (IMTG) has received considerable attention as a potential mechanism promoting insulin resistance. Endurance-trained athletes have high amounts of IMTG but are insulin sensitive, suggesting IMTG content alone does not change insulin action. Recent data suggest increased muscle lipid synthesis protects against fat-induced insulin resistance. We hypothesized that rates o...

Weight loss induced by endurance exercise is often disappointing, possibly due to an increase in energy intake mediated through greater appetite. The aim of this study was to evaluate fasting, postprandial, and postexercise appetite regulation after an intervention prescribing two amounts of endurance exercise. Sixty-four sedentary, overweight, healthy young men were randomized to control (CON)...

OBJECTIVE Exercise training has several well-established health benefits, including many related to body weight, appetite control, and blood glucose homeostasis. However, the molecular mechanisms and, in particular, the hormonal systems that mediate and integrate these beneficial effects are poorly understood. In the current study, we aimed to investigate the role of the hormone ghrelin and its...