Antiphospholipid syndrome (APS) is typically characterized by increased levels of three classes antiphospholipid antibodies, namely lupus anticoagulant, anti-β2-glycoprotein I (anti-β2GPI), and anticardiolipin antibodies. β2-Glycoprotein (β2GPI) a phospholipid-binding protein composed five domains (DI–V) major antigen in APS. β2GPI expressed on the surfaces several cell types, including endothe...

Introduction: Human adipose-derived mesenchymal stem cells (hADSCs) are easily accessible in the body, and under appropriate conditions, they can be directed toward various phenotypes. Therefore, hADSCs have been considered as a potential cell source for tissue engineering applications. hADSCs are able to differentiate into endothelial cells which covers the interior surface of vessels, in vi...

purpose: to evaluate endothelial cell density (ecd) and morphology of clear corneal grafts after descemet stripping automated endothelial keratoplasty (dsaek) and to determine the factors that influence graft ecd postoperatively. methods: seventy-seven eyes (38 right eyes) of 64 patients (34 female subjects) who underwent dsaek for fuchs’ endothelial dystrophy (n=38) or pseudophakic bullous ker...

Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...

Albumin-binding proteins identified in vascular endothelial cells have been postulated to contribute to the transport of albumin via a process involving transcytosis. In the present study, we have purified and characterized a 57- to 60-kDa (gp60) putative albumin-binding protein from bovine pulmonary microvessel endothelial cells. The endothelial cell membranes were isolated from cultured cells...

background : type 1 diabetes mellitus (t1dm) is an autoimmune disease characterized by selective destruction of pancreatic beta cells.   methods: the study included 80 children, 20 of them have t1dm, 40 children were selected from first degree relatives to the same child and 20 healthy children serve as control. body mass index (bmi) was calculated, random blood glucose and glycosylated hemoglo...

INTRODUCTION Perioperative blood transfusion is associated with reduced prognosis in a number of solid malignancies. We investigate its role in a head & neck squamous cell cancer (HNSCC) cell lines. Growth of these cell lines was analogous to endothelial growth. Direct exposure to transfusion products exaggerated this effect. It was logical therefore to assess the effects of anti-endothelial an...