Research into the endocannabinoid signaling system has grown exponentially in recent years following the discovery of cannabinoid receptors (CB) and their endogenous ligands, such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Important advances have been made in our understanding of the endocannabinoid signaling system in various aspects of alcoholism, including alcohol-seeking behavio...

BACKGROUND Cannabinoids have deleterious effects on prefrontal cortex (PFC)-mediated functions and multiple evidences link the endogenous cannabinoid (endocannabinoid) system, cannabis use and schizophrenia, a disease in which PFC functions are altered. Nonetheless, the molecular composition and the physiological functions of the endocannabinoid system in the PFC are unknown. METHODOLOGY/PRIN...

The endocannabinoid system is involved in various physiological pathways the human body. A large number of endogenous cannabinoids have been acknowledged, and cannabinoid receptor type 1 (CB-1) 2 (CB-2) categorized.

The use of cannabis is a well-established component risk factor for schizophrenia, particularly in adolescent individuals with genetic predisposition for the disorder. Alterations to the endocannabinoid system have been found in the prefrontal cortex of patients with schizophrenia. Thus, we assessed whether molecular alterations exist in the endocannabinoid signalling pathway during brain devel...

The endocannabinoid system (ECS) has been implicated in many physiological functions, including the regulation of appetite, food intake and energy balance, a crucial involvement in brain reward systems and a role in psychophysiological homeostasis (anxiety and stress responses). We first introduce this important regulatory system and chronicle what is known concerning the signal transduction pa...

Recent advances in the neurobiology of cannabinoids have renewed interest in the association between cannabis and schizophrenia. Our studies showed that chronic-intermittent phencyclidine (PCP) treatment of rats, an animal model of schizophrenia-like cognitive deficit, impaired recognition memory in the novel object recognition (NOR) test and induced alterations in CB1 receptor functionality an...

AIMS This review posits that fatty acid amide hydrolase (FAAH) inhibition has therapeutic potential against neuropathological states including traumatic brain injury; Alzheimer's, Huntington's, and Parkinson's diseases; and stroke. MAIN METHODS This proposition is supported by data from numerous in vitro and in vivo experiments establishing metabolic and pharmacological contexts for the neuro...

Hepatic fibrosis is the response of the liver to chronic injury and is associated with portal hypertension, progression to hepatic cirrhosis, liver failure, and high incidence of hepatocellular carcinoma. On a molecular level, a large number of signaling pathways have been shown to contribute to the activation of fibrogenic cell types and the subsequent accumulation of extracellular matrix in t...

Endocannabinoid synthesizing 2-AG and cannabinoid receptors have been reported in some organ of reproductive system oocyte ovary, but little is known about the expression subcellular localization CB1 DAGL-α interstitial gland tissue mouse ovary. The aim this study was to explain differential distribution endocannabinoid glandular cell DAGL-α-immunoreactivities were detected within cells, which ...

The following disquisition utilizes the principles of biomolecular psychology to examine biopsychological efficacy nutraceutical medications targeting Female Endocannabinoid System (FECS), particularly concerning Type 2 diabetic (T2DM) women suffering from depression. Theoretical frameworks psychoneuroimmunology linked with endocannabinoid deficiency theories and behavioral nutrition provide ev...