Capillary electrophoresis (CE) was used to optimize the buffer pH, ionic strength and sulfated cyclodextrin concentrations for enantiomeric separation of piperoxan. These enantioseparation conditions were then applied to a classical gel electrophoresis system. Binding constants of the sulfated beta-cyclodextrin-piperoxan couple were approximated using CE and the effects of organic solvents on t...

In this work, the phase-transitioned BSA (PTB) film using mild and fast fabrication process adhered to capillary inner wall uniformly, fabricated PTB film-coated column was applied realize open tubular electrochromatography (OT-CEC) enantioseparation. The enantioseparation ability of evaluated with eight pairs chiral analytes including drugs neurotransmitters, all achieving good resolution symm...

A supramolecular chiral host consisting of N-(2-naphthoyl)-L-aspartic acid (L-1) and meso-1,2-diphenylethylenediamine (2) is effective in enantioseparation of 1-arylethanols (up to 96% ee with 100% inclusion ratio). Here we report three different methods to prepare the inclusion crystals and discuss the chiral recognition mechanism on the basis of X-ray crystallography results.

analytical chemistry has experienced, as well as other areas of science, a big change due to the needs and opportunities provided by analytical nanoscience and nanotechnology. now, nanotechnology is increasingly proving to be a powerful ally of analytical chemistry to achieve its objectives, and to simplify analytical processes. moreover, the information needs arising from the growing nanotechn...

A ligand exchange HPLC method for enantioseparation of ofloxacin enantiomers was developed by a using C8 stationary phase. Chromatographic separation was performed on a Zorbax-300SB-C8 column eluted with the mobile phase consisting of 15 % methanol in water containing 10mM phenylalanin and 5 mM CuSO4 at flow rate of 0.8 mL/min. The method was simple, rapid and suitable for routine analytical st...

We explore the spatial enantioseparation of gaseous chiral molecules for cyclic three-level systems coupled with three electromagnetic fields. Due to molecular rotations, specific requirements polarization directions fields lead space-dependent part overall phase coupling strengths. Thus, strengths, which differs $\pi$ enantiomers in model molecules, varies intensely length scale typical wavele...

Chiral metallic drugs are becoming the hottest point of discussion in field medicinal chemistry. As we know that more than 80% chiral nature, and prescribed racemic form. The main problem with is different biological activities enantiomers. This because human body has a environment, as there presence protein, carbohydrates, enzymes, other macromolecules. Hence, if anticancer drug being to patie...