Methylphenidate induces reanimation (active emergence) from general anesthesia in rodents, and recent evidence suggests that dopaminergic neurotransmission is important in producing this effect. Dextroamphetamine causes the direct release of dopamine and norepinephrine, whereas atomoxetine is a selective reuptake inhibitor for norepinephrine. Like methylphenidate, both drugs are prescribed to t...

Some patients with intellectual disabilities spend longer than others in emergence from ambulatory general anesthesia for dental treatment. Although antiepileptic drugs and anesthetics might be involved, an independent predictor for delay of the emergence remains unclear. Thus, a purpose of this study is to identify independent factors affecting the delay of emergence from general anesthesia. T...

BACKGROUND A recent study showed that methylphenidate induces emergence from isoflurane general anesthesia. Isoflurane and propofol are general anesthetics that may have distinct molecular mechanisms of action. The objective of this study was to test the hypothesis that methylphenidate actively induces emergence from propofol general anesthesia. METHODS Using adult rats, the effect of methylp...

5 January 2013 D OPAMINERGIC neurotransmission is prominently implicated in emergence from the minimal conscious state,1,2 general anesthesia,3 and in sleep–wake regulation.4 The molecular mechanisms for these effects are still incompletely understood. The anatomical and neurochemical signatures of the dopamine (DA) system for arousal under conditions of general anesthesia are clinically import...

purpose : to evaluate efficacy, complications, and patient satisfaction using local anesthesia (la), in comparison to with general anesthesia (ga) in external dacryocystorhinostomy (dcr) methods : in this prospective study, 149 patients with complete nasolacrimal duct (nld) obstruction who were candidates for external dcr were randomized in 2 groups: ga 73 patients, and la 76 patients. intraope...