plus intravenous corticoid administration within the first 36 hours may be sufficient to achieve healing, while surgical debridement is required in the case of late diagnosis. On the other hand, it may become complicated with infection and life-threatening conditions such as necrotizing fasciitis, myositis or sepsis, limb gangrene, paraplegia, or death [4]. Moreover, the area of poorly vascular...

Local complications associated with glatiramer acetate are frequent, especially at the injection site. The presence of pain, oedema, and local erythema is almost a given in areas where the drug is administered subcutaneously. However, the presence of cutaneous necrosis should alert doctors to the possibility of impairment of underlying vascular structures. Nicolau syndrome or embolia cutis medi...

BACKGROUND Controversy still exists about the treatment of rhinitis medicamentosa and treatment has never been objectively evaluated. OBJECTIVE To study the effect of fluticasone propionate aqueous nasal spray compared to placebo nasal spray in the treatment of rhinitis medicamentosa. METHODS A parallel randomized, double-blind study was conducted to evaluate the treatment of rhinitis medic...

BACKGROUND The aim was to study the peculiarities of differential diagnosis, prevention and treatment of different forms of rhinitis in Kazakhstan children and adolescents. METHODS 124 children and adolescents aged 1-17 years were randomly enrolled in our hospital based study in 2010 and 2011. Skin prick tests and total serum IgE level were assessed in all allergic patients. Subcutaneous spec...

 We report a case of Nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. This case is unique because she developed compartment syndrome in her left calf far from her injection site. Her toe’s tips gangrened in the course of her ailment. We hypothesized that the compartment syndrome might be produced by a probable intra-arteri...

Congenital cutis laxa is an exceptional condition. No large scale pedigree has been reported from Iran. We report a family with 106 members with two members affected with cutis laxa. Our cases were two patients (male and female) with pre- and postnatal growth retardation, cutis laxa, characteristic facies and other manifestations which proved that they were affected with cutis laxa. Their ...

congenital cutis laxa is an exceptional condition. no large scale pedigree has been reported from iran. we report a family with 106 members with two members affected with cutis laxa. our cases were two patients (male and female) with pre- and postnatal growth retardation, cutis laxa, characteristic facies and other manifestations which proved that they were affected with cutis laxa. their famil...

cutis laxa is an acquired or inherited condition characterized by redundant, sagging and inelastic skin.  the inherited form is heterogeneous condition with autosomal dominant, autosomal recessive and x-linked inheritance.  autosomal dominant cutis laxa is divided into three types, type i, ii and iii and the responsible genes are eln, fbln5 and aldh18a1 respectively. an x-linked form of cutis l...