BACKGROUND There is some evidence from experimental studies that long-chain n-3 and n-6 fatty acids may be able to modify early skin carcinogenesis, but whether this applies in the general population is not known. METHODS We investigated associations between serum polyunsaturated fatty acid concentrations and p53 expression in normal skin, as a biomarker of early UV-induced carcinogenesis, in...

Goel, Danny P., Thane G. Maddaford, and Grant N. Pierce. Effects of -3 polyunsaturated fatty acids on cardiac sarcolemmal Na /H exchange. Am J Physiol Heart Circ Physiol 283: H1688–H1694, 2002; 10.1152/ajpheart.00664. 2001.—Myocardial ischemia-reperfusion activates the Na /H exchanger, which induces arrhythmias, cell damage, and eventually cell death. Inhibition of the exchanger reduces cell da...

As a contribution to the debate on the comparison of nutritional quality between conventional versus organic products, the present study would like to provide new results on this issue specifically on dairy products by integrating the last 3 years' studies using a meta-analysis approach with Hedges' d effect size method. The current meta-analysis shows that organic dairy products contain signif...

Regular and high consumption of polyunsaturated fatty acids (PUFAs) like DHA (docosahexaenoic acid) prevents the development of age-related macular degeneration (AMD) by acting on oxidative stress. DHA is found in high concentration in the retina. The biochemical properties of DHA influence the fluidity and function of the membrane-photoreceptor [1]. Nutrients from the (Age-related eye disease ...

We studied the incorporation and metabolism of eicosapentanoic (EPA) and docosahexaenoic acid in six human volunteers who supplemented their normal Western diet for 5 mo daily with 10-40 ml of cod liver oil, rich in omega-3 polyunsaturated fatty acids. EPA and docosahexaenoic acid were incorporated into the total phospholipids of plasma, platelets, and erythrocytes in a dose- and time-dependent...

A factorial design was used to study the effect of changes in broiler feed on the composition and consumer acceptability of chicken meat. One week before slaughter, 1.25% dietary fish oil was removed from the feed and replaced by other fat sources (animal fat or linseed oil) or we continued with fish oil, and diets were supplemented with Zn (0, 300, or 600 mg/kg), and Se (0 or 1.2 mg/kg as sodi...

In inflammatory reactions there are complex interactions of protein mediators (cytokines) and mediators derived from lipids. An important event in inflammation is superoxide production, in relation to microbicidal activity as well as tissue damage. We have studied interactions of lipid mediators with a cytokine mediator tumor necrosis factor alpha (TNF) in stimulating superoxide production by h...

Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), has been acknowledged as essential very long-chain fatty acids contributing to either achieving optimal health or protection against diseases, and even longevity. Recent high impact studies dealing with EPA and DHA have sparked a renewed interest in using n-3 PUFAs for cancer ...