BACKGROUND: Skin wounds are a major challenge, such as full-thickness that need long time to heal. However, the addition of erythropoietin can accelerate wound healing process. AIM: This study was aimed determine effect topical administration on vascular endothelial growth factor (VEGF), epidermal (EGF), and epithelialization in METHODS: randomized controlled trial. Full-thickness were created ...

Purpose: To investigate the cytokine concentrations of aqueous humor in patients with exudative age-related macular degeneration (AMD) and diabetic edema (DME).Methods: Fifty-seven subjects were included AMD, DME control groups, each group has 19 patients. Aqueous levels cytokines epidermal growth factor (EGF), vascular endothelial factor-C (VEGF-C), monocyte chemoattractant protein-1 (MCP-1), ...

Abstract A higher concentration of calcium in breast milk than blood favours paracellular absorption enabling growth during postnatal development. We aimed to determine whether suckling animals have greater intestinal permeability maximize and identify the underlying molecular mechanism. examined claudin expression at different ages mice human epithelial (Caco-2) cells response hormones or milk...

We constructed two chimeric toxins; one composed of epidermal growth factor (EGF) and pseudomonas exotoxin A (PE), designated EGF-PE and the other composed of EGF and PE with a deletion of the Ia domain (cell-binding domain), designated EGF-PE (delta Ia). Both chimeric toxins reacted with anti-EGF and anti-PE antibodies. The cell-killing experiments showed that EGF-PE, but not EGF-PE (delta Ia)...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the purpose of this study was to determine the relationship of rs4444903 (egf+61a/g) snp genotype with colorectal cancer and tumor stage in an iranian population. background : epidermal growth factor ( egf ) is one of the important proteins that determine survival of cells. egf binds to its receptor on the cell surface ...

Background: Cultured allogenic keratinocyte (CAK) and epidermal growth factor (EGF) are commonly used biological treatments for partial-thickness burn wounds. A comparative study was conducted on whether the combination therapy of CAK EGF promotes wound healing.Methods: From January 2020 to March 2021, 73 patients who visited hospital with burns were enrolled in study. Patients treated (Kaloder...

Thyroid cancer (TC) is the most prevalent malignant tumor in endocrine system. Serpin peptidase inhibitor clade E member 2 (SERPINE2) closely associated with metastasis. The aim of present study was to investigate whether SERPINE2 forms a feedback loop epidermal growth factor (EGF)/EGF receptor (EGFR) that regulates cellular processes human papillary thyroid carcinoma (TPC‑1) cells. Reverse tra...

Heparin-binding EGF-like growth factor (HB-EGF) is a recently identified member of the EGF family of growth factors and a potent mitogen for smooth muscle cells and fibroblasts. Chinese hamster ovary (CHO) cells genetically engineered to express the human EGF receptor bind with high affinity both EGF and HB-EGF. CHO mutant cells lacking heparan sulfate proteoglycans (HSPG) bind EGF equally well...

epidermal growth factor (egf), a growth factor involved in cell growth and differentiation, is a small polypeptide with molecular weight of approximately 6 kda known to be present in a number of different mammalian species. experimental studies in animals and humans have demonstrated that the topical application of egf accelerates the rate of epidermal regeneration of partial-thickness wounds a...

INTRODUCTION Epidermal growth factor (EGF) is normally present as EGF(1-53). A variety of C terminal truncated forms have been used in preliminary trials for treating gastrointestinal injury but their relative potency and stability when used in a clinical setting are unclear. Therefore, we compared the biological activity of recombinant EGF(1-53), EGF(1-52), EGF(1-51), and the C terminal peptid...