Minimal effective concentration (MEC) was proposed to explain why subcutaneous (SC) administration of erythropoietin (EPO) induces a higher hemoglobin (HGB) increase than intravenous (IV) administration. It has been further used to explain the paradox that erythropoiesis-stimulating agent (ESA) with lower receptor binding affinity may have higher in vivo activity. We have developed a pharmacoki...

17-53 ABSTRACT Both physical form and chemical nature of fiber is important to ruminant animals. A recently developed method for determining particle size distribution was used to characterize typical distributions for forages and total mixed rations (TMR) from the Mid-Atlantic region of the U.S. An effective fiber index (EFI) and modified effective fiber index (MEFI) are proposed which link ph...

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