Denervation induces skeletal muscle atrophy, which primarily impairs oxidative slow twitch fibers. The underlying mechanism of this phenomenon, however, remains to be addressed. We hypothesize that denervation-induced fiber-specific atrophy may result from the distinct activities of different signaling pathways that are involved in protein synthesis and degradation in fast- and slow-twitch fibe...

Changes in mitochondrial function with age vary between different muscle types, and mechanisms underlying this variation remain poorly defined. We examined whether the rate of mitochondrial protein turnover contributes to this variation. Using heavy label proteomics, we measured mitochondrial protein turnover and abundance in slow-twitch soleus (SOL) and fast-twitch extensor digitorum longus (E...

1. Comparisons were made in vitro at 25 degrees C among soleus and extensor digitorum longus (EDL) muscles from young (2-3 months), adult (9-10 months), and aged (26-27 months) male mice. We tested the hypotheses that, compared with soleus and EDL muscles of young and adult mice, those from aged mice develop decreased maximum tetanic force (P0, mN) and specific P0 (N/cm2), and that no significa...

Electric double layer lies in the heart of modern day electrochemical energy storage devices like batteries, fuel cells, supercapacitors and water filtration membranes. The advent of nanostructured rough and porous electrodes has open new possibilities and new challenges. This review summarizes the theoretical development in the electric double layer theory on porous and rough electrodes. Both ...

The response of motoneurones that innervate either the soleus or tibialis anterior (TA) and extensor digitorum longus (EDL) muscles to increased locomotor activity or to nerve injury at different stages after birth was examined. Increased locomotor activity of rat pups was induced by daily treatment with L-dopa during the first 12 days after birth, and the number of surviving motoneurones to th...

This paper describes the IBM systems for English Entity Discovery and Linking (EDL) and Spanish Entity Linking (EL) for the TAC 2014 Knowledge-Base Population track. We submitted two runs for both the EDL and Spanish EL tracks. The linking component of the EDL system achieved an F1 score of 85.0 on the benchmark MSNBC dataset while the Spanish system achieved a B3 + F1 score of 73.6 on the TAC ...

In view of the neuromuscular system plasticity the functional changes induced by partial denervation are presented. The long-term effects of partial denervation of postural (soleus-SOL) or flexor (extensor digitorum longus-EDL) muscles on their EMG activity were studied in rats. The activity per motor unit was significantly higher both in the partially denervated SOL and EDL muscles. During sta...

A descriptive cross-sectional study evaluated the compliance of physicians with the Palestinian essential drug list (EDL) in all the government primary care clinics in the Gaza Strip. While 67.4% reported currently using the EDL 51.2% of these physicians reported problems in using it. The mean number of drugs per prescription was 1.92, the percentage of drugs prescribed from the EDL was 97.9% b...

26 27 To examine the role of sphingosine 1-phosphate (S1P) receptor 3 (S1P3) in modulating muscle 28 properties, we utilized transgenic mice depleted of the receptor. Morphological analyses of extensor 29 digitorum longus (EDL) muscle did not show evident differences between wild type and S1P3-null 30 mice. The body weight of three-month old S1P3-null mice and the mean cross sectional area of 3...

BACKGROUND The diaphragm is resistant to competitive neuromuscular blocking agents. Because of the competitive mechanism of action of tubocurarine, the rate of hydrolysis of acetylcholine at the neuromuscular junction may modulate its neuromuscular blocking effect. The authors compared the neuromuscular blocking effect of tubocurarine on isolated diaphragm and extensor digitorum longus (EDL) mu...