The expression of genes involved in the Sonic Hedgehog signalling pathway, including Shh, Ptc, Smo, Gli1, Gli2 and Gli3, were found to be expressed in temporal and spatial patterns during early murine tooth development, suggestive of a role in early tooth germ initiation and subsequent epithelial-mesenchymal interactions. Of these Ptc, Smo, Gli1, Gli2 and Gli3 were expressed in epithelium and m...

Primitive neuroectodermal tumors (PNETs) are pediatric brain tumors that result from defects in signaling molecules governing the growth and differentiation of neural progenitor cells. We used the RCAS-TVA system to study the growth effects of three genetic alterations implicated in human PNETs on a subset of neural progenitor cells that express the intermediate filament protein, nestin. The ge...

1989; Nakano et al., 1989) that dictates alternative developmental decisions or inhibits growth unless opposed by Hh activity. For example, in ptc mutant fly embryos, the central pattern elements of the ventral epidermis are Stanford University School of Medicine deleted and replaced with mirror-image duplications of Stanford, California 94305 the segment borders (Nü sslein-Volhard and Wieschau...

1989; Nakano et al., 1989) that dictates alternative developmental decisions or inhibits growth unless opposed by Hh activity. For example, in ptc mutant fly embryos, the central pattern elements of the ventral epidermis are Stanford University School of Medicine deleted and replaced with mirror-image duplications of Stanford, California 94305 the segment borders (Nü sslein-Volhard and Wieschau...

1989; Nakano et al., 1989) that dictates alternative developmental decisions or inhibits growth unless opposed by Hh activity. For example, in ptc mutant fly embryos, the central pattern elements of the ventral epidermis are Stanford University School of Medicine deleted and replaced with mirror-image duplications of Stanford, California 94305 the segment borders (Nü sslein-Volhard and Wieschau...

We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline crossing of FasII-positive axonal tracts. In addition, we show that Hh influences axonal guidance via a non-canonical signalling pathway dependent o...

The Drosophila signaling molecule Wingless (Wg) plays crucial roles in cell-cell communications during development. In the developing nervous system, a previous study has shown that Wg acts non-autonomously to specify the fate of a specific neuronal precursor, NB4-2 (Q. Chu-LaGraff and C. Q. Doe (1993) Science 261, 1594-1597). The lack of autocrine specification of NB4-2 in Wg-expressing cells ...

The comparative analysis of the expression reactive oxygen species-generating NADPH oxidase NOX4 from TCGA data shows that transcript is upregulated in papillary thyroid carcinomas (PTC)-BRAFV600E tumors compared to PTC-BRAFwt tumors. However, a at protein level malignant and non-malignant missing. We explored by immunohistochemistry staining (28 classical forms PTC (C-PTC), 17 follicular varia...