Background & Aim: The genus Echinacea (family Asteraceae), commonly known as purple coneflower, is an important medicinal plant that has been used for centuries, customarily as a treatment for the common cold, coughs, bronchitis, upper respiratory infections, and some inflammatory conditions . The present study was carried out to evaluate the effect of six different methods of ...

Background Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides are the main alkamides in Echinacea preparations, which have been demonstrated to possess biological activities in various bio-assays, such as immune-modulating activities and effects on cannabinoid receptors [1]. Therefore, the evaluation of systemic availability of these active plant constituents is a major prerequisite for the i...

ETHNOPHARMACOLOGICAL RELEVANCE The genus Echinacea is a popular herbal immunomodulator. Recent reports indicate that Echinacea products inhibit nitric oxide (NO) production in activated macrophages. AIM OF THE STUDY In the present study we determined the inhibitory effects of alcohol extracts and individual fractions of alcohol extracts of Echinacea on NO production, and explored the mechanis...

Objective. To investigate the safety (risk) and efficacy (benefit) of Echinacea purpurea extract in the prevention of common cold episodes in a large population over a 4-month period. Methods. 755 healthy subjects were allocated to receive either an alcohol extract from freshly harvested E. purpurea (95% herba and 5% root) or placebo. Participants were required to record adverse events and to r...

due to the limited availability of effective pharmaceutical products and serious side effects of the available therapy for leishmaniasis, search for useful medicinal plants is necessary. previous studies reported preventative effect of echinacea against leishmania infections through immunologic stimulation. here we tested concentrated ethanolic extract of the root of echinacea purpurea prepared...

Echinacea preparations, which are used for the prevention and treatment of upper respiratory infections, account for 10% of the dietary supplement market in the U.S., with sales totaling more than $100 million annually. In an attempt to shed light on Echinacea's mechanism of action, we evaluated the effects of a 75% ethanolic root extract of Echinacea purpurea, prepared in accord with industry ...

background: oxidation of lipids causes reduction of different properties of products that contains lipids. nowadays, there is a growing demand for the natural antioxidants due to the harmful effects of synthetic antioxidants such as bha, bht and tbhq. objective: in this study, extract of aerial parts of echinacea purpurea l. was used instead of synthetic antioxidants in cake then, antioxidant a...

BACKGROUND With a traditional medical use for treatment of various ailments, herbal preparations of Echinacea are now popularly used to improve immune responses. One likely mode of action is that alkamides from Echinacea bind to cannabinoid type 2 (CB2) receptors and induce a transient increase in intracellular Ca2+. Here, we show that unidentified compounds from Echinacea purpurea induce cytos...

The goal of this study was to determine whether extracts and isolated alkylamides from Echinacea purpurea would be useful for prevention of the inflammatory response that accompanies infections with H1N1 influenza A. Seventeen extracts and 4 alkylamides were tested for the ability to inhibit production of cytokines, chemokines, and PGE₂ from RAW 264.7 macrophage-like cells infected with the H1N...

the effect of green tea, echinacea purpurea, rosemary extracts on dilation of oxidation and rancidity development in broiler thigh meat was studied. therefore, fresh thighs were dipped in 0.1%  alcoholic aqueous extract during 15 min and kept frozen (-20°c) until 6 months. sampling was carried out at 1, 30, 60, 90, 120,150 and 180 days of aging at -20°c. a parallel experiment with ascorbic acid...