The in vitro activity of a new water-soluble polyene, SPA-S-843, was evaluated against 116 strains of Candida, Cryptococcus, and Saccharomyces spp. and compared with that of amphotericin B. SPA-S-843 demonstrated better inhibitory activity against all of the yeasts examined and better fungicidal activity against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis than did...

Address correspondence to: Shibnath Ghatak, Regenerative Medicine and Cell Biology Anatomy and Division of Rheumatology and Immunology (Department of Medicine), Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425; Tel.: 843-792-8642; Fax: 843792-0664; E-mail: [email protected], or Suniti Misra, Regenerative Medicine and Cell Biology Anatomy and Division of Rh...

Sanguinarine showed strong inhibitory effect against Microcystis aeruginosa, a typical water bloom-forming and microcystins-producing cyanobacterium. The EC50 of sanguinarine against the growth of M. aeruginosa NIES-843 was 34.54±1.17 μg/L. Results of chlorophyll fluorescence transient analysis indicated that all the electron donating side, accepting side, and the reaction center of the Photosy...

, 843 (2014); 344 Science David H. Autor ''other 99 percent'' Skills, education, and the rise of earnings inequality among the This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to re...

Itai and Rodeh [IR] have proved thal for any 2-conncctcd graph G and any vertex S E G there are two spanning trees such that the paths from any othcr vcrtex to s on the trees are disjoint. In this p,aper the result is generalized to 3-connected graphs. T ec hn io n C om pu te r Sc ie nc e D ep ar tm en t T eh ni ca l R ep or t C S0 46 2 19 87 -1

SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.

SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).

Igor Tchivilev, Nageswara R. Madamanchi, Aleksandr E. Vendrov, Xi-Lin Niu, and Marschall S. Runge Department of Medicine, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina 27599-7126 Running Title: PP1cγ1 regulates apoptosis in vascular smooth muscle cells 1 Both authors contributed equally to this work. *Address for Correspondence:Marschall S. Ru...