Axin, Ccd1 (coiled-coil-DIX1), and dishevelled (Dvl or Dsh) are three known DIX domain proteins that play important roles in Wnt signaling. In addition, Dvl and Axin can activate the mitogen-activated protein kinase JNK via distinct mechanisms, through interaction with MEKK1/4 and Rac GTPase, respectively. Axin utilizes two distinct domains for interaction with MEKK1 and MEKK4. JNK activation b...

OBJECTIVES To ascertain determinants and impact of the duration of exclusive breastfeeding (EBF) for four to six months on growth and incidence of respiratory tract and diarrhoeal infections DESIGN AND SETTING A descriptive cross-sectional study of infants aged 4-6 months, visiting selected well baby clinics in Colombo. MEASUREMENTS An interviewer administered questionnaire to determine dur...

The duration of exclusive breastfeeding (EBF) is often defined as the time from birth to the first non-breast milk food/liquid fed (EBFLONG), or it is estimated by calculating the proportion of women at a given infant age who EBF in the previous 24 h (EBFDHS). Others have measured the total days or personal prevalence of EBF (EBFPREV), recognizing that although non-EBF days may occur, EBF can b...

In most aphid species, facultative parthenogenetic reproduction allows rapid growth and formation of large single-genotype colonies. Upon predator attack, individual aphids emit an alarm pheromone to warn the colony of this danger. (E)-beta-farnesene (EBF) is the predominant constituent of the alarm pheromone in Myzus persicae (green peach aphid) and many other aphid species. Continuous exposur...

OBJECTIVE To assess the relationships between maternal breast-feeding intention, attitudes, self-efficacy and knowledge at 7 months' gestation with exclusive or full breast-feeding at 3 months postpartum. DESIGN Prospective cohort study with structured home interviews during pregnancy and 3 months after delivery. SETTING Two rural sub-districts of Kishoreganj district, Bangladesh. SUBJECT...

The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. Different pathways diverge at this point by a mechanism that remains unclear. Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation. In Xenopus, Wnt-regulated convergent...

ishevelled (DVL) is associated with axonal microtubules and regulates microtubule stability through the inhibition of the serine/threonine kinase, glycogen synthase kinase 3 (GSK-3 ). In the canonical WNT pathway, the negative regulator Axin forms a complex with -catenin and GSK-3 , resulting in -catenin degradation. Inhibition of GSK-3 by DVL increases -catenin stability and TCF transcriptiona...

To identify novel regulators of Wnt signaling, we performed yeast two-hybrid analyses with Dvl-1 and identified BP75 as a candidate. Here, we demonstrated that BP75 directly interacts with Dvl-1 in mammalian cells and enhances TCF-dependent gene expression induced by Dvl-1. In support of these results, BP75 in cooperation with Dvl-1 was found to facilitate dephosphorylation at Tyr216 of glycoge...

The rate of Exclusive Breastfeeding (EBF) varies from 23% to 47% in Iran. Few studies have utilized an appropriate theoretical framework to investigate the continuation of EBF behavior. Resorting to the theory of planned behavior (TPB), this study was carried out to determine factors affecting EBF among women referred to health centers. Using multi-stage sampling method, 373 women were selected...

Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway. In Drosophila epithelia, a polarised subcellular accumulation of PCP core components, such as Dishevelled (Dvl) protein, is associated with PCP function. Dvl has long been thought to accumulate in the mediolateral protrusio...