Rational mutation of proteins based on their structural and dynamic characteristics is a useful strategy for amplifying specific fluctuations in proteins. Here, we show the effects of mutation on the conformational fluctuations and thermodynamic stability of ubiquitin. In particular, we focus on the salt bridge between K11 and E34 and the hydrogen bond between I36 and Q41, which are predicted t...

5. Simón P, Sánchez-Yus E, Requena L. La glándula ecrina y la glándula apocrina de la piel humana normal. In: Requena L, editor. Neoplasias anexiales cutáneas. Madrid: Grupo Aula Médica; 2004. p. 3. 6. Zouboulis C, Tsatsou F. Trastorno de las glándulas sudoríparas apocrinas. In: Wolff, Goldsmith, Katz, Gilchrest, Paller, Leffell, editors. Fitzpatrick. Dermatología en Medicina General. 7.a ed. B...

PURPOSE The purpose of this study was to formulate and characterize experimental antibacterial fluoride-releasing sealants and compare them with commercial sealants for fluoride release, recharge, adhesion, and microleakage. METHODS Two experimental sealants (Exp-1, Exp-2) containing a synthesized antibacterial fluoride-releasing monomer and fluoride-releasing filler were formulated. Exp-2 al...

February 2005 | Volume 2 | Issue 2 | e34 Over the last hundred years, there have been major triumphs in medicine related to public health, vaccination, and the introduction of new medicines. However, over the same period, several diseases have increased in prevalence and/or severity. In some cases, the causes of the increase have become obvious—the increases in lung cancer, coronary artery dise...

In adulthood, the copulatory system in male green anole lizards is characterized by the presence of two hemipenes, each controlled by ipsilateral muscles. These structures are present in both sexes early in development, but prior to hatching regress completely in females. Embryonic treatment with steroid hormones alters the morphology of the copulatory system, suggesting active roles for both a...

To evaluate the frequency and clinicopathological features of ROS1 and RET rearrangements in N2 node positive stage IIIA (IIIA-N2) non-small cell lung cancer (NSCLC) patients, we retrospectively screened 204 cases with a tissue microarray (TMA) panel by fluorescent in situ hybridization (FISH), and confirmed by direct sequencing and immunohistochemistry (IHC). The relationship between ROS1 or R...

This Working Paper should not be reported as representing the views of the IMF. The views expressed in this Working Paper are those of the author(s) and do not necessarily represent those of the IMF or IMF policy. Working Papers describe research in progress by the author(s) and are published to elicit comments and to further debate. In this paper, we identify the groups of countries where inte...

The changes in the axon and growth cone numbers in the optic nerve of the freshwater turtle Mauremys leprosa were studied by electron microscopy from the embryonic day 14 (E14) to E80, when the animals normally hatch, and from the first postnatal day (P0) to adulthood (5 years on). At E16, the first axons appeared in the optic nerve and were added slowly until E21. From E21, the fibre number in...

Circulating tissue factor (TF) is an important determinant of coronary thrombosis. Among other cell types, such as monocytes, vascular smooth muscle cells (SMCs) are capable of releasing TF. When studied under static conditions, SMCs do release TF, but this process is slow and, thus, cannot explain the elevated levels of circulating TF, as observed in patients with acute coronary syndromes. The...

We present an analysis of {\it in situ} and remote-sensing measurements a coronal mass ejection (CME) that erupted on 2021 February 20 impacted both the Solar TErrestrial RElations Observatory (STEREO)-A Wind} spacecraft, which were separated longitudinally by 55$^\circ$. Measurements 24 at spacecraft are consistent with passage magnetic ejecta (ME), making this one widest reported multi-spacec...