FHL1 is multifunctional and serves as a modular protein binding interface to mediate protein-protein interactions. In skeletal muscle, FHL1 is involved in sarcomere assembly, differentiation, growth, and biomechanical stress. Muscle abnormalities may play a major role in congenital clubfoot (CCF) deformity during fetal development. Thus, identifying the interactions of FHL1 could provide import...

In the neocortex, the effectiveness of potential cellular repopulation therapies for diseases involving neuronal loss may depend critically on whether newly incorporated cells can differentiate appropriately into precisely the right kind of neuron, re-establish precise long-distance connections, and reconstruct complex functional circuitry. Here, we test the hypothesis that increased efficiency...

Fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) have both been reported to stimulate precursors in the developing CNS. To clarify these effects, we used clonal analysis to determine the lineage potential of precursors stimulated with each factor, at two stages of development. It was found that in cells isolated from the cerebrum of embryonic day 17 (E17) mice, FGF-2 stimula...

To report a rare interaction between known pathogenic alpha variant (--SEA deletion) with another variant, Hb Ube-2 [α68 (E17) Asn →Asp] among our population. This finding may support the current classification of as benign or likely variant. date, limited data available in literature describing this abnormal hemoglobin compound heterozygous state Identification patient confirmed that these var...

The following articles are being highlighted as part of Circulation: Cardiovascular Imaging’s Topic Review. This series summarizes the most important articles, as selected by the editors, that have published in the Circulation portfolio. The studies included in this article represent the most significant research in the area of structural heart disease, cardiac function, aortic disease, and mol...

The hypothalamic-pituitary-gonadal axis (HPG) is a complex neuroendocrine circuit involving multiple levels of regulation. Kisspeptin neurons play essential roles in controlling the HPG axis from the perspectives of puberty onset, oscillations of gonadotropin releasing hormone (GnRH) neuron activity, and the pre-ovulatory LH surge. The current studies focus on the expression of kisspeptin durin...