Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is being used in oncology as a noninvasive method for measuring properties of the tumor microvasculature. There is potential for DCE-MRI to be used as an imaging biomarker to measure antiangiogenic effects of cancer treatments. This article reviews the general methodology for performing DCE-MRI and discusses existing data and challe...

The goals of this meta-analysis were to assess the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with prostate carcinoma (PCa) and to explore the risk profiles with the highest benefit. Systematic electronic searched were conducted in database. We used patient-based and biopsy-based pooled weighted estimates of the sensitivity, specificity, and a su...

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a powerful protocol for assessing tumour progression from changes in tissue contrast enhancement. Manual colorectal tumour delineation is a challenging and time consuming task due to the complex enhancement patterns in the 4D sequence. There is a need for a consistent approach to colorectal tumour segmentation in DCE-MRI and we p...

Dear Editor, Primary pure osteosarcoma of the breast is a rare malignant tumour and is histologically indistinguishable from conventional osteosarcoma of the bone and other extraskeletal sites. Being a rare entity that is briefl y reported in the radiology literature, it has some interesting imaging features worthy of discussion. Here we report the novel fi ndings of dynamic contrast-enhanced M...

The current state-of-the-art assessment of treatment response in breast cancer is based on the response evaluation criteria in solid tumors (RECIST). RECIST reports on changes in gross morphology and divides response into one of four categories. In this paper we highlight how dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) may be able to offer ...

With the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments with distinct pharmacokinetics. However, intratumor vascular heterogeneity cannot be resolved directly by most in vivo dynamic imaging. We developed multi-tissue compartme...

  We report an unusual case of a young male with cerebellar hemangioblastoma treated previously for medullary carcinoma of thyroid, whose PET/CT scans revealed a constellation of findings that suggested the rare Von Hippel Lindau syndrome. The diagnosis was clinched by confirming the findings on whole body contrast enhanced computed tomography (CECT) and contrast enha...

A method is presented for acquiring and visualising physiological parameters using dynamic contrast-enhanced magnetic resonance imaging (CE-MRI). To enable reliable, in vivo measurements of contrast agent uptake, an MRI acquisition is performed using an optimised T1 measurement scheme. Pharmacokinetic modelling of contrast uptake is then performed to obtain physiological parameters relating to ...

PURPOSE To identify the optimal combination of pharmacokinetic model and arterial input function (AIF) for quantitative analysis of blood perfusion in the patellar bone using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS This method design study used a random subset of five control subjects from an Institutional Review Board (IRB)-approved case-control ...