The ligands of certain G-protein coupled receptors (GPCRs) are membrane soluble and reach their target from the lipid bilayer. Lipid composition and dynamics will therefore modulate the activity of these receptors, but specific roles of lipid components, including the ubiquitous cholesterol (Chol), are not clear. We have probed the organization and dynamics of such a lipid-bilayer-penetrating l...

Certain peptides such as dynorphin A [dynA-(1-13)] enhance the release of antigenic peptides bound to class II MHC molecules at neutral pH. This enhanced release has been termed push off. Previous work has shown that the antigenic pigeon cytochrome c peptide PCC-(89-104) has at least two conformational isomers when bound to the class II MHC protein I-Ek. We have accordingly studied the push off...

Sutton's Dyna framework provides a novel and computationally appealing way to integrate learning, planning, and reacting in autonomous agents. Examined here is a class of strategies designed to enhance the learning and planning power of Dyna systems by increasing their computational eeciency. The beneet of using these strategies is demonstrated on some simple abstract learning tasks.

Membrane dynamics are involved in crucial processes in eukaryotic and prokaryotic cells. Membrane fusion and fission events are often catalyzed by proteins that belong to the dynamin family of large GTPases. It has recently been shown that members of the dynamin superfamily are also present in many bacterial species. Although structural information about full length bacterial dynamin-like prote...

In a Role-Playing Game, finding optimal trajectories is one of the most important tasks. In fact, the strategy decision system becomes a key component of a game engine. Determining the way in which decisions are taken (online, batch or simulated) and the consumed resources in decision making (e.g. execution time, memory) will influence, in mayor degree, the game performance. When classical sear...

We present the first version of a new declarative programming language. Dyna has many uses but was designed especially for rapid development of new statistical NLP systems. A Dyna program is a small set of equations, resembling Prolog inference rules, that specify the abstract structure of a dynamic programming algorithm. It compiles into efficient, portable, C++ classes that can be easily invo...

We present the first version of a new declarative programming language. Dyna has many uses but was designed especially for rapid development of new statistical NLP systems. A Dyna program is a small set of equations, resembling Prolog inference rules, that specify the abstract structure of a dynamic programming algorithm. It compiles into efficient, portable, C++ classes that can be easily invo...

We describe the use of the Uro Dyna-CT, an imaging system used in the operating room that produces real-time three-dimensional (3D) imaging and cross-sectional image reconstructions similar to an intraoperative computerized tomography, during a percutaneous nephrolithotomy and a contralateral flexible ureteroscopy in a complete supine position. A 65 year-old female patient had an incomplete cal...

Accurate dynamic modeling and analysis of flexible link manipulator (FLM) with non linear dynamics is very difficult due to distributed link flexibility and few studies have been conducted based on assumed modes method (AMM) and finite element models. In this paper a nonlinear dynamic model with first two elastic modes is derived using combined Euler/Lagrange and AMM approaches. Significant dyn...

LS-DYNA contains a wealth of material models that allow for the simulation of transient phenomena. These models are often quite complex and difficult to calibrate. We present CAE Modeler, a generalized pre-processor software used to convert material property data into material parameters for different material models used in CAE. In this paper, CAE Modeler is used to streamline the conversion o...