Abstract Study question Is dydrogesterone exposure during early pregnancy associated with the reporting of birth defects ? Summary answer We observed an increased defects, such as congenital heart and hypospadias, dydrogesterone, especially compared to progesterone use. What is known already In assisted reproductive technology (ART), intravaginal administration standard care overcome luteal pha...

BACKGROUND: in patients of the reproductive period with endometrial hyperplasia without atypia (EH), issue choosing hormonal treatment and prognosis response to it remains relevant.
 AIM:to increase effectiveness therapy for EH age abnormal uterine bleeding (AUB), taking into account data on receptivity proliferative activity endometrium.
 METHODS:179 AUB were examined. After removal ...

Background The aim of the study was to observe the changes in blood oxidative stress levels by oral contraceptive (OC) and/or dydrogesterone (DG) treatment. Methods A retrospective cohort of 27 premenopausal women with primary dysmenorrhea consisted of the OC treatment group (N = 17) and the DG treatment group (N = 10) by choice of the initial treatment. The OC group included two subgroups: p...

The phenomenon of pregnancy can be compromised by a number of complications, such as threatened abortion, recurrent spontaneous miscarriage, preeclampsia, and preterm delivery. Research conducted during the last decade has opened up the possibility that cellular immune effectors may underlie such pregnancy complications. Particularly interesting are the effects of pro-inflammatory and anti-infl...

We measured basal plasma prolactin concentrations (in samples obtained during the early follicular phase) in 25 normal (control) women and in a similar group of 40 patients with a long-standing history of infertility. The infertile patients were all ovulating regularly, and had been unsuccessfully treated with clomiphene and in some cases dydrogesterone and human menopausal gonadotrophin. Altho...