Around 40% of high-risk prostate cancer patients who undergo radiotherapy (RT) will experience biochemical failure. Chemotherapy, such as docetaxel (DTX), can enhance the efficacy of RT. Multidrug resistance mechanisms often limit drug efficacy by decreasing intracellular concentrations of drugs in tumor cells. It is, therefore, of interest to develop nanocarriers of DTX to maintain the drug in...

Heat stress (HS) is a major problem experienced by the poultry industry during high-temperature conditions. The ability to manage the detrimental effects of HS can be attributed to multiple factors, including genetic background of flocks. The objective of the present study was to determine the genetic variation in HS effects on laying hens' physiological homeostasis. Ninety 28-wk-old White Legh...

We carry out a two-dimensional study of temperature, entropy and pressure distributions in a nearly volume-limited subsample of REFLEX clusters at redshift 0.3, the REFLEX-DXL. We use the observations gained by XMM-Newton, which cover the central 1−2× r500. We define the substructure in both entropy and pressure as a deviation from the mean profile of the sample. The non-parametric locally weig...

The aim of the study was to explore long-term effects seven years after the completion of a ten-year community-based osteoporosis intervention program in Vadstena, Sweden. The association between calcaneal bone mineral density and several life style factors, and the impact of risk factors for sustaining a fracture after the age of 50 were also studied. Previous participants in the intervention ...

DNA glycosylases must interrogate millions of base pairs of undamaged DNA in order to locate and then excise one damaged nucleobase. The nature of this search process remains poorly understood. Here we report the use of disulfide cross-linking (DXL) technology to obtain structures of a bacterial DNA glycosylase, MutM, interrogating undamaged DNA. These structures, solved to 2.0 angstrom resolut...

Let e1, e2, . . . , en denote the standard orthogonal basis of R. Suppose that Λ Λ R is the linear space of all l-vectors, spanned by the exterior product eI ei1∧ei2∧· · ·∧eil corresponding to all ordered l-tuples I i1, i2, . . . , il , 1 ≤ i1 < i2 < · · · < il ≤ n. Throughout this paper, we always assume that Ω is an open subset of R. We use D′ M,Λ to denote the space of all differential l-for...